| 耐药性妊娠滋养细胞肿瘤的临床观察 |
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| 引用本文： | 孙婷婷,邓燕杰,刘佳,焦澜舟,于晓辉,王佳媛.耐药性妊娠滋养细胞肿瘤的临床观察[J].临床肿瘤学杂志,2013,18(6):549-552. |
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| 作者姓名： | 孙婷婷 邓燕杰 刘佳 焦澜舟 于晓辉 王佳媛 |
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| 作者单位： | 116033.辽宁大连 大连市妇幼保健院妇科 |
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| 摘 要： | 目的 探讨耐药性妊娠滋养细胞肿瘤（GTN）的临床病理特征、治疗及预后。方法 收集15例GTN患者的临床资料进行回顾性分析。结果 15例患者治疗均以化疗为主，其中单纯化疗10例，化疗联合手术5例。治疗结束时获血清学完全缓解12例，部分缓解3例。经6～117个月随访，3例失访，余12例无复发或死亡。结论 耐药性GTN的治疗以化疗为主。对于病灶持续存在或血清人绒毛膜促性腺激素β亚单位下降不理想的患者，联合手术治疗可改善预后。
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| 关 键 词： | 妊娠滋养细胞肿瘤 耐药 化学治疗 手术 |
| 收稿时间： | 2012-12-01 |
| 修稿时间： | 2013-02-07 |
Clinical observation of drug-resistant gestational trophoblastic neoplasia |
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| SUN Tingting,DENG Yanjie,LIU Jia,JIAO Lanzhou,YU Xiaohui,WANG Jiayuan.Clinical observation of drug-resistant gestational trophoblastic neoplasia[J].Chinese Clinical Oncology,2013,18(6):549-552. |
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| Authors: | SUN Tingting DENG Yanjie LIU Jia JIAO Lanzhou YU Xiaohui WANG Jiayuan |
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| Affiliation: | Department of Gynaecology， Maternity and Child Health Hospital of Dalian， Dalian 116033， China |
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| Abstract: | Objective To investigate the clinical features, treatment and prognosis of drug-resistant gestational trophoblastic neoplasia （GTN）. Methods The clinical data of 15 GTN patients was retrospectively analyzed. Results The 15 cases of drug-resist- ant GTN were mainly treated by chemotherapy. Among them, there were 10 cases treated by chemotherapy and 5 cases treated by chemotherapy combined with operation. When treatment finished, 12 cases got serologically complete remission and 3 were partial re- mission, respectively. The patients were followed up for 6-117 months with 3 cases lost to follow up, and no relapse occurred or death in the other 12 cases. Conclusion The drug-resistant GTN are mainly treated by chemotherapy. For those with drug-resistant lesions and abnormal serum β-human chorionic gonadotrophin, the treatment of chemotherapy combined with surgery can improve the progno- sis. |
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| Keywords: | Gestational trophoblastie neoplasia Drug-resistant Chemotherapy Surgery |
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