| 粒细胞集落刺激因子影响肿瘤转移的研究进展 |
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| 引用本文： | 梁梦婷,于宏杰,许建华.粒细胞集落刺激因子影响肿瘤转移的研究进展[J].中国肿瘤临床,2019,46(15):790-794. |
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| 作者姓名： | 梁梦婷 于宏杰 许建华 |
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| 作者单位： | 上海中医药大学附属普陀医院中医肿瘤科(上海市 200062) |
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| 基金项目： | 国家自然科学基金项目81573940上海市卫生和计划生育委员会科研项目20184Y0322上海市普陀区卫生系统自主创新科研项目15-PT-02 |
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| 摘 要： | 粒细胞集落刺激因子（granulocyte colony stimulating factor，G-CSF）也称为集落刺激因子3（colony stimulating factor 3，CSF3），是一种含有174个氨基酸的糖蛋白（19.6 KDa）。G-CSF是控制骨髓祖细胞增殖和分化为中性粒细胞的主要造血细胞因子。当宿主受到感染或有组织损伤时，G-CSF可动员中性粒细胞。临床上G-CSF多用于放、化疗患者，预防或治疗放化疗后所造成的中性粒细胞减少症或发热性中性粒细胞减少症。G-CSF可通过动员肿瘤相关中性粒细胞促进肿瘤生长和转移。本文就G-CSF对肿瘤生长、转移的促进作用和可能机制进行综述。
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| 关 键 词： | 粒细胞集落刺激因子 粒细胞集落刺激因子受体 肿瘤转移 进展 |
| 收稿时间： | 2019-06-11 |
Research advances in the effect of G-CSF on tumor metastasis |
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| Affiliation: | Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China |
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| Abstract: | Granulocyte colony stimulating factor (G-CSF), also known as colony stimulating factor 3 (CSF3), is a glycoprotein (19.6 KDa) consisting of 174 amino acids. G-CSF is a major hematopoietic cytokine that controls the proliferation and differentiation of myeloid progenitor cells into neutrophils. G-CSF can also mobilize neutrophils when the host is infected or has tissue damage. In clinical practice, G-CSF is frequently used to prevent or treat neutropenia or febrile neutropenia caused by radiotherapy and chemotherapy. Recent studies have also shown that G-CSF can promote tumor growth and metastasis by mobilizing tumor-associated neutrophils. This article reviews the role and possible mechanism of G-CSF in promoting tumor growth and metastasis. |
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