| 肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值 |
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| 引用本文： | 颜彬,陈慧君,高晗,谭文福,蔡鸿宁,周志刚,戴璇,朱发霞,熊雨静,徐檬,郭玉琳,邹苗,吴绪峰.肿瘤相关CD66b阳性中性粒细胞对预测宫颈癌Ⅰb至Ⅱa期复发的价值[J].中国肿瘤临床,2017,44(21):1071-1075. |
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| 作者姓名： | 颜彬 陈慧君 高晗 谭文福 蔡鸿宁 周志刚 戴璇 朱发霞 熊雨静 徐檬 郭玉琳 邹苗 吴绪峰 |
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| 作者单位： | ①.湖北省妇幼保健院肿瘤妇科（武汉市 430070） |
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| 基金项目： | 本文课题受国家自然青年科学基金项目(81502265)，武汉市科技计划项目(编号:2015061701011647)资助
This work was supported by the National Natural Science Foundation of China(81502265)，the Key Project of National Health and Family Planning Commission of Hubei Province(WJ2015MA017)，the Natural Science Foundation of Hubei Province(2015CFB381)，the Scientific Research Project of Wuhan Science and Technology Bureau(2015061701011647) |
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| 摘 要： | 目的 :探讨宫颈癌组织中的多形核嗜中性粒细胞（polymorphnuclear neutrophil，PMN）数量在预测宫颈癌复发中的作用。 方法 回顾性分析1999年2月至2006年12月湖北省妇幼保健院及武汉大学中南医院92例初治宫颈癌Ⅰb~Ⅱa期患者的临床病理资料。采用免疫组织化学法检测宫颈癌组织中阳性CD66b的PMN数量，计算PMN数量平均值。将患者按宫颈癌组织中PMN浸润数量分组，数量 > PMN平均值为A组，数量≤PMN平均值为B组。以无复发生存（recurrence free survival，RFS）为结点，采用Kaplan-Meier法进行单因素分析，采用Cox风险回归模型进行多因素分析。 结果 A组的RFS期明显短于B组（P=0.001）。单因素及Cox风险回归模型多因素分析结果显示，腺癌（HR为3.020，95%CI为1.340~6.805，P=0.008）、淋巴结转移（HR为2.450，95%CI为1.065~5.637，P=0.035）、PMN浸润数量增加（HR为2.866，95%CI为1.274~46.447，P=0.011）为宫颈癌患者RFS的独立危险因素。 结论 宫颈癌组织中PMN数量的增加与宫颈癌患者RFS期缩短相关，是宫颈癌患者预后不良的一个潜在预测指标。
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| 关 键 词： | 宫颈癌 预后 中性粒细胞 复发 |
| 收稿时间： | 2017-05-29 |
Value of tumor-associated CD66b-positive neutrophils for the prediction of the recur-rence of stage Ib and IIa cervical cancer |
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| Bin YAN,Huijun CHEN,Han GAO,Wenfu TAN,Hongning CAI,Zhigang ZHOU,Xuan DAI,Faxia ZHU,Yujing XIONG,Meng XU,Yulin GUO,Miao ZOU,Xufeng WU.Value of tumor-associated CD66b-positive neutrophils for the prediction of the recur-rence of stage Ib and IIa cervical cancer[J].Chinese Journal of Clinical Oncology,2017,44(21):1071-1075. |
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| Authors: | Bin YAN Huijun CHEN Han GAO Wenfu TAN Hongning CAI Zhigang ZHOU Xuan DAI Faxia ZHU Yujing XIONG Meng XU Yulin GUO Miao ZOU Xufeng WU |
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| Affiliation: | ①.Department of Gynecologic Oncology, Hubei Maternity and Child Health Hospital, Wuhan 430070, China②.Department of Gynecology and Obstetrics, Zhongnan Hospital, Wuhan University, Wuhan 430071, China |
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| Abstract: | Objective:To investigate the prognostic effect of polymorphnuclear neutrophil (PMN) in cervical cancer. Methods:Patients (n=92) who underwent curative surgery for the treatment of stage Ib and IIa cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) were assessed to determine their tumor-infiltrating CD66b-positive neutrophils through immuno-histochemistry. Assessment results were then analyzed to identify their correlation with recurrence-free survival (RFS) as an end point. Kaplan-Meier method was used for survival curve analysis, and a Cox proportional hazard model was utilized for univariate and multi-variate analyses. Results:The RFS of the group with a density of CD66b-positive neutrophils above the median in cervical cancer tis-sues was significantly shorter than that of the group with a density of CD66b-positive neutrophils below the median (P=0.001). Univari-ate and multivariate analyses revealed adenocarcinoma (HR=3.020;95%CI=1.340-6.805;P=0.008), lymph node metastasis (HR=2.450;95%CI=1.065-5.637;P=0.035), and high neutrophil density (HR=2.866;95%CI=1.274-46.447;P=0.011) as independent prognostic fac-tors of short RFS. Conclusion:The increasing number of tumor-infiltrating neutrophils in cervical cancer tissues was correlated with short RFS of patients with cervical cancer. |
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| Keywords: | cervical cancer prognosis neutrophil recurrence |
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