| 绿原酸在脑胶质瘤治疗中的应用前景 |
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| 引用本文： | 杨靖怡,杨守博,康庄,康勋,李文斌.绿原酸在脑胶质瘤治疗中的应用前景[J].中国肿瘤临床,2018,45(5):256-259. |
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| 作者姓名： | 杨靖怡 杨守博 康庄 康勋 李文斌 |
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| 作者单位： | 首都医科大学附属北京世纪坛医院脑胶质瘤科（北京市100038） |
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| 基金项目： | 国家科技重大新药创制科技重大专项“十三五”项目2016ZX09101017 |
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| 摘 要： | 恶性神经胶质瘤作为常见的原发性颅内肿瘤，占所有中枢神经系统恶性肿瘤的81%。经手术联合体外放疗、化疗等标准治疗方案后，胶质母细胞瘤（glioblastoma，GBM）患者的生存期仅为14.4个月，传统治疗难以满足患者对生存期及生存质量的要求。近年来，绿原酸（chlorogenic acid，CGA）作为植物提取多酚类物质，其调节免疫系统、抗氧化、调控细胞周期、抑制肿瘤细胞转移和侵袭等多种抗肿瘤作用机制受到广泛关注及深入研究。本文将从绿原酸类物质在胶质瘤治疗领域的作用机制、与其他药物协同以及人体内代谢等相关研究展开总结与讨论，旨在为胶质瘤治疗中绿原酸的应用提供一定参考。
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| 关 键 词： | 绿原酸 脑胶质瘤 治疗 |
| 收稿时间： | 2017-12-01 |
The prospect of chlorogenic acid in the treatment of glioma |
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| Affiliation: | Department of Brain Glioma, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China |
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| Abstract: | As a common primary intracranial tumor, malignant glioma accounts for 81% of all central nervous system malignancies. After standard treatment, such as surgery combined with external radiotherapy and chemotherapy, glioblastoma patients' survival is only 14.4 months. Hence, the traditional treatment is difficult to meet patients' needs of survival and life quality. In recent years, chlorogenic acid (CGA), as plant extract polyphenols, has received widespread attention. Its antitumor properties, through its effects on the immune system, anti-oxidation properties, cell cycle regulation, and inhibition of tumor cell metastasis and invasion, have been extensively studied. This article will discuss the mechanisms involved in glioma treatment, synergism with other drugs, and metabolism in the human body, to provide a reference for the application of CGA in the treatment of the condition. |
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