| H3K27M和Ki-67在小儿脑胶质瘤中的表达及相关性 |
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| 引用本文： | 胡历博,刘伟,朱晋,柴毅,张玉琪.H3K27M和Ki-67在小儿脑胶质瘤中的表达及相关性[J].中国肿瘤临床,2020,47(12):609-613. |
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| 作者姓名： | 胡历博 刘伟 朱晋 柴毅 张玉琪 |
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| 作者单位： | ①.清华大学临床医学院(北京市 100084) |
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| 摘 要： | 目的:探讨H3K27M和Ki-67在小儿脑胶质瘤组织中的表达及意义。方法:收集2013年11月至2018年6月清华大学玉泉医院38例小儿脑胶质瘤和10例正常脑组织,采用免疫组织化学检测H3K27M和Ki-67表达并结合相关统计学方法进行分析。结果:H3K27M阳性表达与性别、年龄、肿瘤部位无显著性差异(P>0.05),但与肿瘤病理级别有显著性相关(P<0.05)。Ki-67在胶质瘤中阳性表达率为100%,Ki-67高标记指数与性别、年龄无显著性相关(P>0.05),与病理级别、肿瘤部位有显著性相关(P<0.05)。患儿的性别、年龄与生存时间之间无显著性差异(P>0.05),病理分级、肿瘤部位、H3K27M蛋白阳性、Ki-67高标记指数在患儿生存时间之间有显著性差异(P<0.05)。结论:小儿脑胶质瘤中H3K27M、Ki-67的表达水平对小儿脑胶质瘤的病理分级、预后具有提示意义,且H3K27M、Ki-67蛋白在胶质瘤组织中的表达具有相关性,为研究胶质瘤的发生发展及靶向治疗提供了线索。
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| 关 键 词： | 儿童 胶质瘤 KI-67 H3K27M 免疫组织化学 |
| 收稿时间： | 2020-04-27 |
Expression and correlation of H3K27M and Ki-67 in pediatric glioma |
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| Libo Hu,Wei Liu,Jin Zhu,Yi Chai,Yuqi Zhang.Expression and correlation of H3K27M and Ki-67 in pediatric glioma[J].Chinese Journal of Clinical Oncology,2020,47(12):609-613. |
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| Authors: | Libo Hu Wei Liu Jin Zhu Yi Chai Yuqi Zhang |
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| Affiliation: | ①.School of Clinical Medicine, Tsinghua University, Beijing 100084, China②.Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China③.Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing 100040, China |
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| Abstract: | Objective To investigate the expression and significance of H3K27M and Ki-67 in pediatric glioma. Methods Immunohistochemistry was used to detect the expression of H3K27M and Ki-67 in 38 patients with pediatric glioma and 10 patients with normal brain tissue, who enrolled in Yuquan Hospital, Tsinghua University from November 2013 to June 2018. The results were analyzed using appropriate statistical methods. Results The positive expression of H3K27M was not significantly correlated with gender, age, and tumor site (P>0.05). However, it was significantly correlated with the tumor pathological grade (P < 0.05). The positive expression rate of Ki-67 in pediatric glioma was 100%. The high label index of Ki-67 was not significantly correlated with gender and age (P>0.05). However, it was significantly correlated with the pathological grade and tumor site (P < 0.05). There were no significant correlations between the ptients' gender, age, and survival time (P>0.05). There were significant correlations between the tumor pathological grade, tumor location, H3K27M protein-positive, Ki-67 high label index, and patient survival time (P < 0.05). Conclusions The expression level of H3K27M and Ki-67 appeared to be related to the pathological grade and prognosis of pediatric glioma. Besides, the expression of H3K27M and Ki-67 protein in glioma tissue were correlated. This could be useful for studying the occurrence and development of glioma as well as investigating potential targeted therapy options. |
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| Keywords: | children glioma Ki-67 H3K27M immunohistochemistry |
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