| 乳腺癌微环境中巨噬细胞相关因子与环氧化酶-2的调节 |
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| 引用本文： | 陈伟贤,赵建华.乳腺癌微环境中巨噬细胞相关因子与环氧化酶-2的调节[J].中国肿瘤临床,2013,40(13):811-814. |
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| 作者姓名： | 陈伟贤 赵建华 |
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| 作者单位： | ①.南京医科大学附属肿瘤医院, 江苏省肿瘤医院普外科（南京市210009） |
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| 摘 要： | 肿瘤微环境中浸润的巨噬细胞(tumor-associated macrophages, TAMs)是近年来癌症治疗的新靶点。TAMs通过分泌大量促癌细胞因子如血管内皮生长因子、白细胞介素、基质金属蛋白酶等, 促进肿瘤细胞增殖、侵袭和转移。炎症因子环氧化酶-2(cyclooxygenase-2, COX-2)参与了微环境中血管形成和免疫调节, 加速肿瘤进程, 也是乳腺癌治疗的有力靶点。而COX-2抑制剂如塞来昔布, 在抑制TAMs活性和改善肿瘤微环境方面具有较大潜力。因此, 本文就乳腺癌微环境中TAMs分泌的重要细胞因子与COX-2的相互关系加以讨论, 分析其对应的拮抗剂单独或与COX-2抑制剂联合的使用价值, 旨在为选择多靶点联合阻断TAMs活性的研究提供理论基础, 也为乳腺癌的生物靶向治疗提供新方向。
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| 关 键 词： | 微环境 乳腺癌 环氧化酶-2免疫 肿瘤相关巨噬细胞 |
| 收稿时间： | 2012-12-28 |
Crosstalk between macrophage-delivered cytokines and cyclooxygenase-2 in breast cancer microenvironment |
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| Weixian CHEN
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Jianhua ZHAO
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Jinhai TANG.Crosstalk between macrophage-delivered cytokines and cyclooxygenase-2 in breast cancer microenvironment[J].Chinese Journal of Clinical Oncology,2013,40(13):811-814. |
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| Authors: | Weixian CHEN Jianhua ZHAO Jinhai TANG |
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| Affiliation: | ①.Department of General Surgery, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210009, China②.Center of Clinical Laboratory Center, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210009, China |
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| Abstract: | A new target in cancer treatment involves tumor-associated macrophages(TAMs) which are infiltrated in microenvironment.By secreting a wide range of cancer-promoting cytokines, such as vascular endothelial growth factor, interleukins, and matrix metalloproteinase, TAMs can promote the proliferation, invasion, and metastasis of cancer cells.Cyclooxygenase-2(COX-2), an inflammatory factor that is significant for angiogenesis and immunoregulation within the local microenvironment, may also contribute to cancer progression and act as a novel target for breast cancer therapy.Several COX-2 inhibitors, such as celecoxib, have shown potential as suppressors of TAMs and the microenvironment.Hence, the current study discusses the crosstalk between TAMs-delivered important cytokines and COX-2 in the breast cancer microenvironment, and then analyzes the value of homologous antagonists alone or in combination with COX-2 inhibitors.This paper aims to provide the theoretical principle of multi-target selection in TAMs blockage, and offer a new direction for biological targeted therapy in breast cancer treatment. |
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| Keywords: | microenvironment breast cancer cyclooxygenase-2 immunity tumor-associated macrophage |
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