| bBMP-胶原-珊瑚复合人工骨修复股骨头骨缺损的生物力学研究 |
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| 引用本文： | 徐小良,王坤正,杨增华,牒军,党晓谦,阎宏伟,李旭东,张开放,陈君长.bBMP-胶原-珊瑚复合人工骨修复股骨头骨缺损的生物力学研究[J].中国骨伤,2001,14(1):17-19. |
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| 作者姓名： | 徐小良 王坤正 杨增华 牒军 党晓谦 阎宏伟 李旭东 张开放 陈君长 |
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| 作者单位： | 西安医科大学第二附属医院,陕西 西安 710004 |
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| 摘 要： | 目的 研究用bBMP－胶原－珊瑚复合人工骨修复股骨头骨缺损的生物力学变化。方法 建立狗双侧股骨头内骨缺损模型，4周后分为5组：复合人工骨且、肌骨瓣组、单纯珊瑚组、对照组、正常组。植入后16周行病理学检查及生物力学测定。结果 人工骨组的骨缺损消失或显著变小，与对照组相比有显著性差异。人工骨组软骨下骨的抗压强度及弹性模量较对照组及正常组低。结论 复合人工骨有较强的修复股骨头骨缺损的能力，但不能改善软骨下骨的生物力学性能。
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| 关 键 词： | 股骨头坏死 骨质再生 生物力学 人工植入物 |
| 收稿时间： | 1999/9/22 0:00:00 |
| 修稿时间： | 1999年9月22日 |
A biomechanical study of bBMP-collagen-coral composited bone substitute for the treatment of canine bone defect of the femoral head |
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| XU Xiao liang,WANG Kun zheng,YANG Zeng hua.A biomechanical study of bBMP-collagen-coral composited bone substitute for the treatment of canine bone defect of the femoral head[J].China Journal of Orthopaedics and Traumatology,2001,14(1):17-19. |
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| Authors: | XU Xiao liang WANG Kun zheng YANG Zeng hua |
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| Abstract: | Objective To study the biomechanical changes of bBMP-collagen-coral composited bone substitute for the treatment of canine bone defect of the femoral head.Methods Canine bone defect of bilateral femoral head was established.After 4 weeks,they were divided into 5 groups:Ⅰ.composited bone substitute group;Ⅱ.Muscle pedicle bone group;Ⅲ.simple coral group;Ⅳ.control group;Ⅴ.normal group.Pathological and biomechanical changes of femoral head were studied at 16 weeks after treatment.Results Compared with control group,the bone defect of group I was much smaller.The maximum stress and modulus of elasticity of subchondral bone of group I were lower than that of group V and group Ⅳ.Conclusion The composited bone substitute possesses a superior property for repairing bone defect of femoral head,but it is unable to improve the biomechanical property of subchondral bone of femoral head. |
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| Keywords: | Femur head necrosis Osteosis Biomechanics Implants artificial |
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