| 上海市新生儿乙肝疫苗持久性和加强免疫研究 |
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| 引用本文： | 李燕婷,袁国娟,张家琪,施锦明,申惠国,袁国平,吴寰宇,沈荣明,沈薇娟.上海市新生儿乙肝疫苗持久性和加强免疫研究[J].疾病监测,2000,15(7):245-248. |
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| 作者姓名： | 李燕婷 袁国娟 张家琪 施锦明 申惠国 袁国平 吴寰宇 沈荣明 沈薇娟 |
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| 作者单位： | 1.上海市疾病预防控制中心; |
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| 摘 要： | 新生儿乙肝血源疫苗全程接种后 5～ 9年抗 -HBs阳性率和滴度 (MIU/ml)明显下降 ,约75%抗 -HBs水平在保护性水平 ( <10MIU/ml)以下。但乙肝表面抗原HBsAg阳性率与免疫后一年比较无明显差异 ,仍有很好保护效果。应用 5μg乙肝基因疫苗加强免疫一剂 ,再免后一个月抗 -HBs阳性率和滴度 (MIU/ml)明显升高 ,分别提高 28.60 %和 2.90倍 ,对抗 -HBs <10MIU/ml的儿童加强免疫有较好免疫回忆反应。
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| 关 键 词： | 乙型肝炎疫苗 加强免疫 抗-HBs |
| 收稿时间： | 2000-04-03 |
| 修稿时间： | 2000年4月3日 |
Study on Immune Persistence and Boost Vaccination of Hepatitis B Vaccine in Newborns Shanghai |
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| Li Yanting.Study on Immune Persistence and Boost Vaccination of Hepatitis B Vaccine in Newborns Shanghai[J].Disease Surveillance,2000,15(7):245-248. |
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| Authors: | Li Yanting |
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| Affiliation: | 1.Shanghai Center for Disease Prevention and Control;Shanghai;200031 |
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| Abstract: | Both the positive seroconversion rate and titer of anti HBs(Miu/ml) in the newborns who have been vaccinated with plasma derived hepatitis B vaccine in 1988～1992 have decreased markedly.About 75 percent of the newborns' antibody titer of anti-HBs was less than the protective titer level (<10 Miu/ml).But there was no significant difference in the positive seroconversion rate of HBsAg between pre-vaccination and one year after vaccination. It still has a good protective effect.After one month of vaccination with one dose(5μg)recombined yeast hepatitis B vaccine boost,the positive seroconversion rate and titer of anti-HBs have risen by 28.60% and 20.9% respectively.There was good recall reaction with boost vaccination in the children whose anti-HBs titer were less than 10 mIU/ml. |
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| Keywords: | Hepatitis B vaccine Boost vaccination Anti-HBs |
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