| 轻度认知损伤患者海马杏仁核体积的MRI测量及临床随访研究 |
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| 引用本文： | 解恒革,程流泉,王鲁宁,蔡幼铨.轻度认知损伤患者海马杏仁核体积的MRI测量及临床随访研究[J].中国医学影像技术,2001,17(2):136-138. |
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| 作者姓名： | 解恒革 程流泉 王鲁宁 蔡幼铨 |
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| 作者单位： | 1. 解放军总医院老年医学研究所南楼神经科，
2. 核磁共振室 |
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| 基金项目： | 本研究受军队“九五”课题资助(98M139)和国家卫生部“九五”攻关课题资助(96-906-05-07)。 |
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| 摘 要： | 目的 探讨轻度认知损伤（MCI）患者海马，杏仁核萎缩在Alzheimer病（AD）发病中的作用，方法 MCI组11例，AD组15例，正常老年人14例，GE 1．5T MR机，3D－FSPGR序列采样，冠状位，层厚1．3mm，层数60，计算机三维重建并进行杏仁核海马体积测量，经标准化校正后进行比较，随访MCI患者进展为AD的情况，结果 AD组海马杏仁核体积萎缩25％（P＜0．05），MCI组萎缩5－13％（P＞0．05），27．3％的MCI患者经1年随访进展为AD。结论 伴海马 杏仁核萎缩的MCI患者更易于进展为AD。
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| 关 键 词： | Alzheimer病 轻度认知损伤 MRI 海马 |
| 文章编号： | 1003-3289（2001）02-0136-03 |
| 收稿时间： | 2000/8/24 0:00:00 |
| 修稿时间： | 2000年8月24日 |
MRI-based Hippocampus and Amygdala Volumes in Mild Cognitive Impairment and Follow-up Study |
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| XIE Heng-ge,CHENG Liu-quan,WANG Lu-ning and CAI You-quan.MRI-based Hippocampus and Amygdala Volumes in Mild Cognitive Impairment and Follow-up Study[J].Chinese Journal of Medical Imaging Technology,2001,17(2):136-138. |
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| Authors: | XIE Heng-ge CHENG Liu-quan WANG Lu-ning and CAI You-quan |
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| Abstract: | Objective To investigate the prediction of Alzheimer disease (AD) with MRI based hippocampus and amygdala volumes in mild cognitive impairment(MCI). Methods 15 patients with AD, 11 with MCI and 14 normal elderly were examined by GE 1.5T MR machine using 3D FSPGR sequence, 1.3mm slice thickness, 60 slices. The 3 dimensional reconstruction of hippocampus and amygdala was performed and measured on the Sunwork Station. The normalized volumes were analyzed, and one year follow up study was performed in MCI patients. Results The AD patients had significantly smaller volumes of hippocampus and amygdala (-25%, P <0.05) compared to controls. The reduction of MCI in hippocampus and amygdala was mild(-5% to -13%, P >0.05). After one year follow up, 27.3% in MCI met the criteria of AD. Conclusion Hippocampus and amygdala atrophy of MCI may be a predictor of developing AD. |
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| Keywords: | Alzheimer disease Mild cognitive impairment Magnetic resonance imaging Hippocampus |
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