| 血清PLGF和sFLT-1水平联合检测对急性ST段抬高型心肌梗死患者PCI术后MACE复发的诊断价值研究 |
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| 引用本文： | 蔡文灿,刘熙君,刘彦明,李彤,肖帅,陈伟娟.血清PLGF和sFLT-1水平联合检测对急性ST段抬高型心肌梗死患者PCI术后MACE复发的诊断价值研究[J].现代检验医学杂志,2021,0(2):66-69. |
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| 作者姓名： | 蔡文灿 刘熙君 刘彦明 李彤 肖帅 陈伟娟 |
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| 作者单位： | （粤北人民医院a.输血科；b.检验科，广东韶关 512026） |
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| 基金项目： | 韶关市卫生和计划生育委员会科研项目(Y19041)。 |
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| 摘 要： | 目的 探讨血清胎盘生长因子（PLGF）和可溶性fms样酪氨酸激酶-1(sFLT-1)在急性ST段抬高型心肌梗死（ST-AMI）患者经皮冠状动脉介入治疗（PCI）后心血管不良事件（MACE）复发中的价值。方法 选取2018年1月~2019年1月收治的ST-AMI患者230例作为研究对象，入院后均及时进行PCI治疗，入院后第12日检测PLGF和sFLT-1水平并随访一年。根据随访期间内是否复发MACE，研究对象被分为MACE组（68例）和对照组（162例），比较两组间血清PLGF和sFLT-1水平并分析其对ST-AMI患者PCI术后MACE复发的价值。结果 MACE组的PLGF和sFLT-1检测水平分别为22.56±5.99 pg/ml和189.58±69.94 pg/ml；对照组的PLGF和sFLT-1检测水平分别为32.71±7.90 pg/ml和141.52±59.76 pg/ml，结果显示MACE组的PLGF表达水平明显低于对照组，差异具有统计学意义（t=10.57，P<0.000 1）；而sFLT-1表达水平明显高于对照组，差异具有统计学意义（t=5.372，P<0.000 1）。血清PLGF和sFLT-1单独检测的灵敏度、特异度和ROC曲线下面积（AUROC）分别为80.25%，53.47%，0.766 和74.07%，58.82%，0.697，联合检测的灵敏度、特异度和AUROC分别为77.90%，72.8%和0.820。结论 血清PLGF和sFLT-1检测可用于ST-AMI患者PCI术后MACE复发的早期诊断且联合检测的灵敏度和特异度更高。
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| 关 键 词： | 胎盘生长因子 可溶性fms样酪氨酸激酶-1 急性ST段抬高型心肌梗死 |
Combined Detection of Serum PLGF and SFLT-1 Levels in the Diagnosis of MACE Recurrence after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction |
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| CAI Wen-can,LIU Xi-jun,LIU Yan-ming,LI Tong,XIAO Shuai,CHEN Wei-juan.Combined Detection of Serum PLGF and SFLT-1 Levels in the Diagnosis of MACE Recurrence after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2021,0(2):66-69. |
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| Authors: | CAI Wen-can LIU Xi-jun LIU Yan-ming LI Tong XIAO Shuai CHEN Wei-juan |
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| Affiliation: | （a. Department of Blood Transfusion；b. Department of Clinical Laboratory, Yuebei People’s Hospital , Guangdong Shaoguan 512026, China） |
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| Abstract: | Objective To explore the diagnostic value of serum placental growth factor(PLGF)and soluble fms-like tyrosine kinase-1(SFLT-1)levels in the recurrence of major adverse cardiovascular events(MACE)after the percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(ST-AMI).Methods A number of 230 patients with ST-AMI admitted from January 2018 to January 2019 in Yuebei People’s Hospital were included.The PCI treatment was performed in time and remission was achieved within 12 days after admission.The venous blood was collected on the 12th day on a fasting stomach and serum was separated.The patients were followed up for one year and divided into the MACE group(68 cases)and the control group(162 cases)according to their MACE recurrence.The difference of serum PLGF and SFLT-1 concentrations and the MACE diagnostic value between the two groups were compared.Results The serum PLGF level in the MACE group(22.56±5.99 pg/ml)was significantly lower than that of the control group(32.71±7.90 pg/ml)(t=10.57,P<0.0001).The serum SFLT-1 level in the MACE group(189.58±69.94 pg/ml)was significantly higher than that of the control group(141.52±59.76 pg/ml)(t=5.372,P<0.0001).The sensitivity,specificity,and AUROC of serum PLGF and SFLT-1 levels were 80.25%,53.47%,0.766 and 74.07%,58.82%,0.697,respectively.The sensitivity,specificity,and AUROC of the combined detection of serum PLGF and sFLT-1 were 77.90%,72.8%and 0.820,respectively.Conclusion Serum PLGF and SFLT-1 can be used for early diagnosis of MACE recurrence after PCI in ST-AMI patients,and combined detection has higher sensitivity and specificity. |
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| Keywords: | placental growth factor soluble fms-like tyrosine kinase-1 acute ST-segment elevation myocardial infarction |
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