| 急性脑缺血患者血清IGFBP-4和PLGF水平与颈动脉斑块不稳定性的相关性研究 |
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| 引用本文： | 张 盼,薛 伟a,张 熊b,孔 维c.急性脑缺血患者血清IGFBP-4和PLGF水平与颈动脉斑块不稳定性的相关性研究[J].现代检验医学杂志,2021,0(5):124-127. |
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| 作者姓名： | 张 盼 薛 伟a 张 熊b 孔 维c |
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| 作者单位： | (1. 商洛市中心医院超声医学科，陕西商洛 726000；2. 咸阳市第一人民医院a. 输血科；b. 检验科；c. 神经内科, 陕西咸阳 712000) |
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| 摘 要： | 目的 探讨急性脑缺血(acute cerebral ischemia，ACI)患者血清胰岛素样生长因子结合蛋白-4(insulin like growth factor binding protein-4,IGFBP-4)和胎盘生长因子(placental growth factor,PLGF)水平的变化与颈动脉斑块不稳定性的相关性。方法 收集2018年6月～2020年6月在商洛市中心医院和咸阳市第一人民医院神经内科住院治疗的105例颈动脉斑块患者作为研究对象。依据患者是否发生ACI分为ACI组(57例)和非ACI组(48例)。采用酶联免疫吸附法检测血清IGFBP-4和PLGF水平。所有研究对象均接受颈动脉超声造影检查。观察患者的斑块厚度、长度、剪切波速度(shear wave velocity，SWV)及回声强度(echo intensity，EI)。比较分析以上指标的变化与颈动脉斑块不稳定性的相关性。结果 非ACI组和ACI组的血清IGFBP-4和PLGF水平分别为5.39±1.43ng/ml，7.27±1.83ng/ml和51.09±3.66ng/L，83.21±7.97ng/L。与非ACI组比较,ACI组的IGFBP-4和PLGF水平显著增高，差异有统计学意义(t=10.210~27.237,均P=0.000)。相关性分析显示，ACI组和非ACI组的血清IGFBP-4和PLGF水平分别呈正相关性(r=0.796，0.750，均P<0.01)。非ACI组的 IGFBP-4和PLGF水平分别与SWV呈负相关性,与EI呈正相关性(rIGFBP-4=-0.823，0.835，均P<0.01；rPLGF=-0.794，0.812，均P<0.01)。ACI组的IGFBP-4和PLGF水平分别与SWV呈负相关性,与EI呈正相关性(rIGFBP-4=-0.833,0.851, 均P<0.01; rPLGF=-0.819, 0.827, P均<0.01)。结论 IGFBP-4和PLGF可能参与颈动脉斑块破裂的病理过程。检测血清IGFBP-4和PLGF水平可对患者颈动脉斑块的不稳定性进行评估进而预测ACI的发生。
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| 关 键 词： | 急性脑缺血 颈动脉斑块 胰岛素样生长因子结合蛋白-4 胎盘生长因子 |
Correlation between the Levels of IGFBP-4, PlGF in Serum and CarotidPlaque Instability in Patients with Acute Cerebral Ischemia |
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| ZHANG Pan,XUE Weia,ZHANG Xiongb,KONG Weic.Correlation between the Levels of IGFBP-4, PlGF in Serum and CarotidPlaque Instability in Patients with Acute Cerebral Ischemia[J].Journal of Modern Laboratory Medicine,2021,0(5):124-127. |
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| Authors: | ZHANG Pan XUE Weia ZHANG Xiongb KONG Weic |
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| Affiliation: | （1.Department of Ultrasound Medicine,Central Hospital of Shangluo City,Shaanxi Shangluo 726000,China;2a.Department of Blood Transfusion; 2b. Department of Clinical Laboratory; 2c. Department of Neurology，the FirstPeople’s Hospital of Xianyang City, Shaa |
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| Abstract: | Objective To investigate the relationship between the changes of serum insulin-like growth factor binding protein-4(IGFBP-4) as well as placental growth factor (PlGF) levels and carotid plaque instability in patients with acute cerebral ischemia.Methods 105 patients with carotid plaque who were hospitalized in the Department of Neurology of the Central Hospital ofShangluo City and the First People’s Hospital of Xianyang City between June 2018 and June 2020 were selected as the researchobjects. According to whether the patients had the acute cerebral ischemia (ACI), they were divided into ACI group (57 cases)and non ACI group (48 cases). The serum levels of IGFBP-4 and PlGF were detected by enzyme-linked immunosorbent assay.Allsubjects underwent carotid ultrasound contrast-enhanced examination.The plaque thickness, length, shear wave velocity (SWV)and echo intensity (EI) were observed.The correlation between the changes of the above indexes and the carotid plaque instabilitywas compared and analyzed. Results The serum levels of IGFBP-4 and PlGF in non ACI group and ACI group were(5.39±1.43,7.27±1.83)ng/ml and (51.09±3.66, 83.21±7.97)ng/L,respectively. Compared with non ACI group,the serum levelsof IGFBP-4 and PlGF in ACI group were significantly higher ,the difference were statistically significant(t=10.210, 27.237, P =0.000).There was a positive correlation between serum IGFBP-4 and PlGF levels in ACI group and non ACI group (r = 0.796,0.750, all P< 0.01).The levels of IGFBP-4 and PlGF in non ACI group were negatively correlated with SWV and were positively correlated with EI (rIGFBP-4=-0.823,0.835, all P<0.01;rPLGF=-0.794,0.812,all P<0.01). The levels of IGFBP-4 and PlGF in ACIgroup were negatively correlated with SWV and were positively correlated with EI(rIGFBP-4=-0.833,0.851,all P<0.01;rPLGF=-0.819,0.827,all P<0.01). Conclusion IGFBP-4 and PlGF may be involved in the pathological process of carotid plaque rupture.Detection of serum IGFBP-4 and PlGF levels can evaluate the carotid plaque instability and predict the occurrence of ACI. |
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