| 三种方法评估替加环素对多重耐药鲍曼不动杆菌体外药敏结果分析 |
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| 引用本文： | 代鑫露,黄松音,李红玉.三种方法评估替加环素对多重耐药鲍曼不动杆菌体外药敏结果分析[J].现代检验医学杂志,2020,0(3):103-106. |
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| 作者姓名： | 代鑫露 黄松音 李红玉 |
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| 作者单位： | （中山大学孙逸仙纪念医院检验科，广州 510120） |
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| 摘 要： | 目的 比较3 种药敏检测方法检测替加环素对多重耐药鲍曼不动杆菌敏感性的差异。方法 收集2018 年临床
分离耐碳青霉烯类鲍曼不动杆菌60 株，采用MIC Test Strip（MTS）法、VITEK-2 法、纸片扩散法分别检测替加环素对
耐碳青霉烯类鲍曼不动杆菌的敏感性。结果 按照FDA 标准，以MTS 法为参考，VITEK-2 法的一致率较高，纸片扩
散法的一致率较低。Vitek-2 法的MIC 值比MTS 法的MIC 值低1 ~ 2 个稀释度，利用MTS 法检测替加环素对耐碳青霉
烯鲍曼不动杆菌的耐药率达到23.3%，出现耐药株。结论 对于耐碳青霉烯类鲍曼不动杆菌，Vitek-2 法和纸片扩散法
均不适合检测替加环素的敏感性，不能作为常规方法，需用MTS 法确认。
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| 关 键 词： | 替加环素 鲍曼不动杆菌 纸片扩散法 MIC Test Strip 法(MTS 法) VITEK-2 法 |
Comparision of Three Susceptibility Testing Methods of Tigecycline Against
Multidrug Resistant Acinetobacter Baumannii |
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| DAI Xin-lu,HUANG Song-yin,LI Hong-yu.Comparision of Three Susceptibility Testing Methods of Tigecycline Against
Multidrug Resistant Acinetobacter Baumannii[J].Journal of Modern Laboratory Medicine,2020,0(3):103-106. |
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| Authors: | DAI Xin-lu HUANG Song-yin LI Hong-yu |
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| Affiliation: | （Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University,Guangzhou 510120,China） |
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| Abstract: | Objective To study the difference of three testing methods on susceptibility results of tigecycline against multidrug
resistant Acinetobacter baumannii (MDR-AB). Methods 60 carbapenem-resistant Acinetobacter baumannii (CRAB) strains
were collected from Sun Yat-Sen Memorial Hospital. Minimum inhibitory concentration(MIC) and inhibitory zone diameters
for tigecycline were determined by Vitek-2, MTS and disk diffusion methods . The results of Vitek-2 and disk diffusion methods
were compared with MTS method . The differences with antimicrobial susceptibility among the three different methods were
evaluated. Results According to FDA standard, the consistency rate of Vitek-2 method was higher than that of paper diffusion
method and Vitek-2 result in MIC90 in 1 dilution was lower compared with MTS.The drug resistance rate of tegacycline to
carbapenems resistant Acinetobacter baumannii was detected by MTS method, which reached 23.3%, and drug-resistant strains
appeared. Conlusion For routine susceptibility testing of MDR-AB on tigecycline, the disk diffusion and Vitek-2 may not be
proper because of the poor correlation of results between the MTS. |
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