| 子痫前期孕妇血清 SOCS3，PP-13，GATA-3水平变化及其预测价值研究 |
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| 引用本文： | 危丽华a,张 新a,封 伟b.子痫前期孕妇血清 SOCS3，PP-13，GATA-3水平变化及其预测价值研究[J].现代检验医学杂志,2022,0(1):48-51. |
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| 作者姓名： | 危丽华a 张 新a 封 伟b |
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| 作者单位： | （衡水市第二人民医院a. 产科；b. 检验科，河北衡水053000） |
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| 摘 要： | 目的 探讨血清细胞因子信号转导负调控因子 -3（SOCS-3）、胎盘蛋白 -13(PP-13)、GATA结合蛋白 3(GATA-
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| 关 键 词： | 细胞因子信号转导负调控因子 -3 胎盘蛋白 -13 GATA结合蛋白 -3 子痫前期 变化 预测 |
Changes of Serum SOCS3, PP-13 and GATA-3 Levels in Preeclampsia and Their Predictive Value |
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| WEI Li-huaa,ZHANG Xina,FENG Weib.Changes of Serum SOCS3, PP-13 and GATA-3 Levels in Preeclampsia and Their Predictive Value[J].Journal of Modern Laboratory Medicine,2022,0(1):48-51. |
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| Authors: | WEI Li-huaa ZHANG Xina FENG Weib |
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| Affiliation: | （a.Department of Obstetrical；b. Department of Clinical Laboratory, the Second People’s Hospital of Hengshui,Hebei Hengshui 053000, China） |
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| Abstract: | Objective To investigate the changes and predictive value of serum SOCS3, pp-13 and GATA-3 in preeclampsiapregnant women. Methods 240 cases of preeclampsia patients treated in the Second People’s Hospital of Hengshui fromJanuary 2018 to January 2020 were selected as the observation group, and 200 pregnant women with normal delivery in thehospital during the same period were selected as the normal group, and 100 cases of pregnant women with simple gestationalhypertension were selected as the control group .In the observation group and the control group, 5ml of elbow venous blood wascollected on the day of diagnosis and pregnancy examination in the normal group. The levels of serum SOCS3, pp-13 and GATA-3 were detected. The changes of the three factors were observed. The correlation between the factors and the severity of thedisease was analyzed by correlation analysis. The specificity and sensitivity of SOCS3, PP-13 and GATA-3 in predictingpreeclampsia were analyzed by ROC curve. Results The serum levels of SOCS3 and GATA-3 in the observation group werelower than those in the control group and the normal group, while the PP-13 level was higher than those in the control group andthe normal group. The levels of SOCS3 and GATA-3 in the control group were lower than those in the normal group, and the PP-13 level was higher than that in the normal group,the differences were statistically significant(t=2.624~53.479, all P ＜ 0.05).Thelevels of SOCS3 and GATA-3 were negatively correlated with the severity of preeclampsia(r=-0.432, -0.397, all P<0.05), whilethe level of PP-13 was positively correlated with the severity(r=0.506, P<0.05), Preeclampsia Logistic regression analysisshowed that SOCS3, PP-13 and GATA-3 levels were risk factors of preeclampsia (P<0.05)， serum SOCS3, PP-13 and GATA-3levels had higher sensitivity and specificity in predicting the incidence of preeclampsia, and the predictive efficacy of combineddetection was higher than that of single detection (P<0.05). Conclusion Serum SOCS3, PP-13 and GATA-3 have great changesin preeclampsia pregnant women. They have good sensitivity and specificity in the prediction of preeclampsia. The combineddetection has higher prediction efficiency and can be widely used in clinical practice. |
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