| 遗忘型轻度认知障碍近十年磁共振成像研究进展 |
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| 作者姓名： | 韩慧婷 祖涵瑜 黄娅楠 陈梦莎 曹赫 张宝亮 姜兴岳 |
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| 作者单位： | 1.滨州医学院附属医院放射科，山东 滨州 2566032.滨州学院人文学院，山东 滨州 256603 |
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| 基金项目： | 山东省自然科学基金ZR2018LH015 |
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| 摘 要： | 随着我国社会老龄化的不断加速，老年痴呆的发病率不断增高，其也是中老年群体的重要死因之一。轻度认知障碍是介于正常脑老化与老年痴呆的一种认知功能障碍状态，遗忘型轻度认知障碍作为其主要分型，是老年痴呆的高危因素。在老年群体中，遗忘型轻度认知障碍发病率高达10%以上。与认知正常的老年人相比，轻度认知障碍患者患痴呆的风险高4~10倍，在此阶段对患者进行有效诊治，可极大延缓患者病情向痴呆转化的进程。目前，遗忘型轻度认知障碍诊断主要依靠临床神经电生理检查及神经影像学检查，近年来随着磁共振成像技术的不断发展，极大提高了遗忘型轻度认知障碍的早期诊断效能，本文对扩散张量成像、基于体素的形态学测量、动脉自旋标记成像、磁共振波谱、酰胺质子转移成像、静息态功能磁共振成像几种磁共振成像技术在遗忘型轻度认知障碍中的应用现状进行综述，以期为临床医生提供帮助。
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| 关 键 词： | 遗忘型轻度认知障碍 磁共振成像 影像学诊断 |
| 收稿时间： | 2022-05-09 |
Research progress of magnetic resonance imaging in amnestic mild cognitive impairment in recent ten years |
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| Authors: | HAN Huiting ZU Hanyu HUANG Yanan CHEN Mengsha CAO He ZHANG Baoliang JIANG Xingyue |
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| Affiliation: | 1.Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China2.College of Humanities, Binzhou University, Binzhou 256603, China |
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| Abstract: | With the accelerating aging of our society, the incidence of senile dementia is increasing. It is also an important cause of death in the elderly. Mild cognitive impairment is a cognitive impairment state between normal brain aging and senile dementia. Amnestic mild cognitive impairment, as its main classification, has become a high risk factor for senile dementia. Compared with the elderly with normal cognition, the risk of dementia in patients with mild cognitive impairment is 4-10 times higher. Therefore, effective diagnosis and treatment of patients in this state stage can greatly delay the progression of patients' disease to dementia. Currently, amnestic mild cognitive impairment diagnosis relies mainly on the clinical neural electrophysiological examination and imaging examination, with the continuous development of magnetic resonance imaging technology in recent years, greatly improve the early detection of amnestic mild cognitive impairment, in this paper, In this paper, several MRI techniques, such as diffusion tensor imaging, voxel-based morphometry, arterial spin labeling, magnetic resonance spectroscopy, amide proton transfer imaging, and resting- state functional magnetic resonance imaging, have been investigated in amnestic mild cognition. The current status of application in disorders is reviewed in order to provide assistance to clinicians. |
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