| 病灶CT密度值指导下行颅内微创血肿清除术对慢性硬膜下血肿患者的疗效 |
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| 作者姓名： | 张渊 罗平 许伟 |
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| 作者单位： | 宜宾市第二人民医院神经外科，四川 宜宾 644000 |
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| 基金项目： | 宜宾市卫生和计划生育委员会科研课题2017yw0010 |
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| 摘 要： | 目的 观察病灶CT密度值指导下颅内微创血肿清除术治疗慢性硬膜下血肿（CSDH）患者疗效及预后影响因素。 方法 回顾性分析2017年12月~2020年12月于我院接受治疗的134例CSDH患者的临床资料，根据手术方法分为观察组（n=74，行病灶CT密度值指导下颅内微创血肿清除术）与对照组（n=60，行常规颅骨钻孔闭式引流术）。比较两组围术期指标，并记录手术前后神经及运动功能中国卒中量表(CSS)、改良Barthel指数(MBI)]及并发症发生。以出院后3月的Markwalder's分级作为预后情况的评估标准，将观察组分为预后不良组及预后良好组，通过单因素及多因素Logistic回归方程分析影响病灶CT密度值指导下颅内微创血肿清除术治疗CSDH预后的危险因素。 结果 两组患者术中出血、术后拔管时间、住院时间差异无统计学意义(P>0.05)，观察组手术时间更长(P<0.05)，术后30 d血肿清除率更高(P<0.05)；CT图像显示，治疗前左侧额颞顶枕部低信号新月形影像，局部占位效应明显，脑组织受压，中线结构移位，治疗后慢性硬膜下血肿钻孔引流术后第1天，引流管留置，硬膜下积液积气表现，局部占位效应减轻，中线结构移位好转；两组患者术前CSS、MBI评分差异无统计学意义(P>0.05)，两组术后30 d的CSS评分较术前降低，MBI评分较术前升高(P<0.05)，且观察组术后CSS评分更低，MBI评分更高(P<0.05)；两组随访3月内均无死亡病例，各项并发症发生率差异无统计学意义(P>0.05)；年龄、脑萎缩及入院时格拉斯哥昏迷评分在预后良好组及预后不良组组间差异有统计学意义(P<0.05)，性别、出现症状到入院时间、血肿量、饮酒史、抽烟史、血肿CT值、术后引流、抗凝药物在预后良好组及预后不良组组间差异无统计学意义(P>0.05)；年龄>65岁及入院时格拉斯哥昏迷评分<13分为影响病灶CT密度值指导下颅内微创血肿清除术治疗CSDH预后的独立危险因素(P<0.05)。 结论 病灶CT密度值指导下颅内微创血肿清除术治疗CSDH效果理想，血肿清除率高，其预后与年龄及入院时格拉斯哥昏迷评分有关。
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| 关 键 词： | CT密度值 颅内微创血肿清除术 慢性硬膜下血肿 疗效 预后 危险因素 |
| 收稿时间： | 2022-06-02 |
Curative effect and prognostic factors of patients with chronic subdural hematoma treated by intracranial minimally invasive evacuation guided by CT density of lesions |
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| Authors: | ZHANG Yuan LUO Ping XU Wei |
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| Affiliation: | Department of Neurosurgery, Second People's Hospital of Yibin City, Yibin 644000, China |
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| Abstract: | Objective To observe the curative effect and prognostic factors of patients with chronic subdural hematoma (CSDH) treated by intracranial minimally invasive evacuation under the guidance of CT density. Methods The clinical data of 134 CSDH patients treated in our hospital from December 2017 to December 2020 were analyzed retrospectively. According to the surgical methods, they were divided into observation group (n=74, minimally invasive evacuation of intracranial hematoma guided by CT density of lesions) and control group (n=60, conventional skull drilling and closed drainage). The perioperative indexes of the two groups were compared, and the neurological and motor functions Chinese stroke scale (CSS), modified Barthel index (MBI)] and complications were recorded before and after operation. Markwalder's grade at 3 months after discharge was taken as the evaluation standard of prognosis, and the observation group was divided into poor prognosis group and good prognosis group. The risk factors affecting the prognosis of CSDH were analyzed by univariate and multivariate Logistic regression equation. Results There were no statistically significant differences in intraoperative bleeding, postoperative extubation time and hospital stay between the two groups (P>0.05). The operation time of the observation group was significantly longer (P<0.05), and the hematoma clearance rate was significantly higher 30 days after surgery (P<0.05). CT images show that before the treatment to the top of the left frontal temporal occipital low signal crescent images, local placeholder effect obvious, compression of brain tissue, midline structure shift, after treatment of chronic subdural hematoma on the first day after drilling drainage, drainage tube indwelling, subdural effusion pneumatosis performance, reduce local placeholder effect, midline structure shift better; There was no statistical significance in preoperative CSS and MBI scores between the two groups (P>0.05). The CSS score of the two groups at 30 days after surgery was significantly lower than that before surgery, while the MBI score was significantly higher than that before surgery(P<0.05). The CSS score of the observation group was lower and THE MBI score was higher after surgery(P<0.05). There was no death in the two groups within 3 months of follow-up, and there was no statistical significance in the incidence of complications (P>0.05). Age, brain atrophy and on admission GCS score in a set of good prognosis and bad prognosis way between the difference was statistically significant (P<0.05). Gender, symptoms to hospital time, hematoma volume, history of drinking, smoking history, hematoma, postoperative drainage, CT value of anticoagulant drugs in good prognosis group were not significantly different from the bad way prognosis (P>0.05). Age>65 years old and GCS score<13 at admission were independent risk factors of prognosis of CSDH after minimally invasive intracranial hematoma removal guided by CT density value (P<0.05). Conclusion Minimally invasive evacuation of intracranial hematoma guided by CT density of lesions is effective in the treatment of CSDH, and its prognosis is related to age and GCS score at admission. |
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