| 血清STK1、ECM1、sB7-H3检测联合多层螺旋CT技术对提高肝细胞癌与肝血管瘤鉴别诊断的临床意义 |
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| 作者姓名： | 陈娅 伍发 蒋锐 陈敏 左智炜 |
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| 作者单位： | 中国人民解放军西部战区总医院放射诊断科，四川 成都 610083 |
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| 基金项目： | 四川省卫生健康委员会科研课题20PJ211 |
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| 摘 要： | 目的 探究血清胸腺苷激酶1（STK1）、可溶型B7-H3（sB7-H3）、细胞外基质蛋白-1（ECM1）联合多层螺旋CT对肝细胞癌与肝血管瘤的鉴别诊断。 方法 选取59例肝细胞癌及45例肝血管瘤患者，比较两种病灶的影像学特征及血清STK1、sB7-H3及ECM1水平；分析多层螺旋CT三期增强扫描对上述两种疾病的诊断效能。 结果 CT平扫显示，肝细胞癌及肝血管瘤病灶的形态特征、类型、边界清晰度的差异有统计学意义（P < 0.05）；肝细胞癌患者的血清STK1、sB7-H3、ECM1水平高于肝血管瘤患者（P < 0.05），且两种患者的动脉期均匀高密度病灶的增强CT值的差异有统计学意义（P < 0.05）；多层螺旋CT三期增强扫描诊断肝细胞癌、肝血管瘤，与病理结果一致性较好（Kappa=0.844）。 结论 多层螺旋CT三期增强扫描可有效鉴别肝细胞癌与肝血管瘤，动脉期均匀高密度病灶的增强CT值及血清STK1、sB7-H3、ECM1水平升高有利于疾病诊断。
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| 关 键 词： | 肝细胞癌 肝血管瘤 多层螺旋CT |
| 收稿时间： | 2022-06-01 |
Clinical significance of serum STK1, ECM1 and sB7-H3 detection combined with multi-slice spiral CT on improving the differential diagnosis of hepatocellular carcinoma and hepatic hemangioma |
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| Authors: | CHEN Ya WU Fa JIANG Rui CHEN Min ZUO Zhiwei |
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| Affiliation: | Department of Radiology, General Hospital of the Western Theater Command of the Chinese People's Liberation Army, Chengdu 610083, China |
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| Abstract: | Objective To explore serum thymidine kinase 1 (STK1), soluble B7-H3 (sB7-H3) and extracellular matrix protein-1 (ECM1) combined with multi-slice spiral CT in the differential diagnosis of hepatocellular carcinoma and hepatic hemangioma. Methods Fifty-nine patients with hepatocellular carcinoma and 45 patients with hepatic hemangioma were selected. The imaging characteristics of the two lesions and levels of serum STK1, sB7-H3 and ECM1 were compared and the diagnostic efficiency of multi-slice spiral CT three-phase enhanced scan on the above two diseases was analyzed. Results CT plain scan results showed that there were significant differences in the morphology, type and boundary between hepatocellular carcinoma lesions and hepatic hemangioma lesions (P < 0.05). The levels of serum STK1, sB7-H3 and ECM1 in patients with hepatocellular carcinoma were higher than those in patients with hepatic hemangioma (P < 0.05). There was a statistical difference in the enhanced CT value of uniform high-density lesions in the arterial phase between two kinds of patients (P < 0.05). Multi-slice spiral CT three-phase enhanced scan in the diagnosis of hepatocellular carcinoma and hepatic hemangioma had good consistency with pathological results (Kappa=0.844). Conclusion Multi-slice spiral CT three-phase enhanced scan is effective in distinguishing hepatocellular carcinoma from hepatic hemangioma. Enhanced CT value of uniform high-density lesions in the arterial phase and increased levels of serum STK1, sB7-H3 and ECM1 are helpful for disease diagnosis. |
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