| 205例HIV阴性梅毒患者脑脊液白蛋白商数及IgG指数分析 |
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| 引用本文： | 郭泽,汤华阳,王再兴,林达,李卉,陈越,赵煦,杨森.205例HIV阴性梅毒患者脑脊液白蛋白商数及IgG指数分析[J].中国麻风皮肤病杂志,2021,37(7):419-423. |
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| 作者姓名： | 郭泽 汤华阳 王再兴 林达 李卉 陈越 赵煦 杨森 |
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| 作者单位： | 1安徽医科大学第一附属医院皮肤性病科，合肥，230022；
2安徽医科大学，合肥，230000 |
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| 摘 要： | 目的：了解HIV阴性梅毒患者中脑脊液白蛋白商数及IgG指数的分布特征。方法：共收集205例梅毒患者脑脊液标本，其中124例非神经梅毒, 81例神经梅毒。使用SPSS 25.0 软件进行统计学分析，计算两组患者白蛋白商数及IgG指数的敏感性、特异性及诊断效率。结果：神经梅毒组白蛋白商数及IgG指数分别为(6.98±3.80)和(1.51±1.16)高于非神经梅毒组(4.63±2.03)和(0.67±0.48),差异有统计学意义(均P＜0.001)。在神经梅毒患者中，脑脊液TRUST阳性患者IgG指数均值为(2.14±1.31)较阴性患者（1.10±0.84）高, 差异有统计学意义(P＜0.001)。白蛋白商数在神经梅毒诊断方面，敏感性为73.33%，特异性66.29%，阳性预测值27.16%，阴性预测值93.55%,诊断效率67.32%。IgG指数在神经梅毒诊断方面，敏感性为59.60%，特异性79.25%，阳性预测值72.84%，阴性预测值67.74%,诊断效率69.76%。结论：白蛋白商数及IgG指数可用于神经梅毒的辅助诊断。
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| 关 键 词： | 梅毒 神经梅毒 脑脊液 白蛋白商数 IgG指数 |
Analysis of albumin quotient and IgG index in 205 HIV-negative syphilis patients |
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| GUO Ze,TANG Huayang,WANG Zaixing,LIN Da,LI Hui,CHEN Yue,ZHAO Xu,YANG Sen.Analysis of albumin quotient and IgG index in 205 HIV-negative syphilis patients[J].China Journal of Leprosy and Skin Diseases,2021,37(7):419-423. |
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| Authors: | GUO Ze TANG Huayang WANG Zaixing LIN Da LI Hui CHEN Yue ZHAO Xu YANG Sen |
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| Affiliation: | 1 Department of Dermatology and Venereology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 2 Anhui Medical University, Hefei 230000, China |
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| Abstract: | Objective: To analyze the albumin quotient (QAlb) and IgG index in HIV-negative syphilis patients. Methods: 205 syphilis inpatients were collected including 124 non-neurosyphilis patients and 81 neurosyphilis patients. The sensitivity, specificity and diagnostic efficiency of QAlb and IgG index was calculated use SPSS 25.0 software. Results: The QAlb and IgG index were (6.98±3.80) and (1.51±1.16) in the neurosyphilis patients which were higher than that in the non-neurosyphilis patients (4.63±2.03 and 0.67±0.48), with significant differences (P<0.001), the IgG index of the neurosyphilis patients was (2.14±1.31) in TRUST positive group, which was higher than that in negative group (1.10±0.84), with a significant difference (P<0.001). The sensitivity of QAlb and IgG index in the diagnosis of neurosyphilis was 73.33% and 59.60%, specificity was 66.29% and 79.25%, positive predictive value was 27.16% and 72.84%, negative predictive value was 93.55% and 67.74%, and the diagnostic efficiency was 67.32% and 69.76%, respectively. Conclusion: The QAlb and IgG index can be used for the auxiliary diagnosis of neurosyphilis. |
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| Keywords: | syphilis neurosyphilis cerebrospinal fluid QAlb IgG index |
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