Adaptive growth changes in the liver remnant are affected by the size of hepatectomy in rats |
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| Authors: | Michelle Meier Kasper Jarlhelt Andersen Anders Riegels Knudsen Jens Randel Nyengaard Stephen Hamilton‐Dutoit Frank Viborg Mortensen |
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| Affiliation: | 1. Section for Upper Gastrointestinal and Hepato‐Pancretico‐Biliary Surgery, Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark;2. Section for Stereology and Microscopy, Department of Clinical Medicine, Centre for Molecular Morphology, Centre for Stochastic Geometry and Advanced Bioimaging, Aarhus University, Aarhus, Denmark;3. Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark |
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| Abstract: | In this study we investigated the dynamics of hepatocyte hyperplasia and hypertrophy in rats subjected to increasing sizes of partial hepatectomy (PH). A total of 104 rats were randomized according to the size of PH. On postoperative days (PODs) 1, 3 and 5, blood was drawn and the remnant liver removed for stereological analysis. Liver parameters and regeneration rate were significantly affected by size of PH. On POD 1, hepatocyte volumes had increased significantly in all PH groups. On POD 3, all groups showed hepatocyte volumes approximating baseline. On POD 5, hepatocyte volumes were significantly lower in PH (90) than in baseline, sham and PH (30) rats. Increasing hepatocyte proliferation was not observed following PH (30). Following PH (70), cell proliferation was significantly elevated on PODs 1 and 3, and following PH (90) on PODs 3 and 5. In conclusion, general hypertrophy of hepatocytes after different size of PH was followed by hepatocyte proliferation only in the liver remnant of PH (70) and PH (90). |
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| Keywords: | hepatic surgery hepatocyte hyperplasia hepatocyte hypertrophy liver regeneration posthepatectomy liver failure |
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