| 一种无线闭环迷走神经刺激器及系统 |
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| 引用本文： | 汤秣雄,李效龙.一种无线闭环迷走神经刺激器及系统[J].中国医学物理学杂志,2022,0(12):1530-1537. |
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| 作者姓名： | 汤秣雄 李效龙 |
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| 作者单位： | 江苏科技大学电子信息学院， 江苏 镇江 212003 |
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| 摘 要： | 为了治疗药物难治性癫痫，提出一种无线闭环迷走神经刺激器及系统，包括头戴式头皮脑电记录器、迷走神经刺激器、电磁耦合能量发射器和控制应用App，设计一种可以分离局部场电位和动作电位的生物信号前置放大器，一种刺激脉冲参数可调的迷走神经刺激器，一种电磁耦合能量发射器以及一个控制应用App。使用海岸线参数检测算法判定癫痫脑电信号的产生。测试结果表明，生物信号前置放大器对局部场电位和动作电位的放大增益分别为40和60 dB。迷走神经刺激器接收到来自控制应用App的刺激参数后，可以产生对应参数的双极性刺激脉冲。当发射器发射功率为30 dBm，发射线圈和接收线圈距离2 cm时，电磁耦合能量传输效率最大为15.4%。海岸线参数算法的正检率为88%。
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| 关 键 词： | 癫痫 脑电信号 生物信号前置放大器 双极性刺激脉冲发生器 电磁耦合 |
Wireless closed-loop vagus nerve stimulator and its system |
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| TANG Moxiong,LI Xiaolong.Wireless closed-loop vagus nerve stimulator and its system[J].Chinese Journal of Medical Physics,2022,0(12):1530-1537. |
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| Authors: | TANG Moxiong LI Xiaolong |
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| Affiliation: | School of Electronic Information, Jiangsu University of Science and Technology, Zhenjiang 212003, China |
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| Abstract: | Abstract: A wireless closed-loop vagus nerve stimulator and its system which includes a head-mounted scalp EEG recorder, a vagus nerve stimulator, an electromagnetic coupling energy transmitter and a control App are proposed for the treatment of drug-refractory epilepsy. A bio-signal preamplifier that can separate local field potential and action potential, a vagus nerve stimulator that can generate biphasic stimulation pulses with adjustable parameters, an electromagnetic coupling energy transmitter and a control App are designed. The coastline parameter algorithm is used to detect the generation of epileptic signals. The test results show that the amplification gains of the bio-signal preamplifier for local field potential and action potential are 40 and 60 dB, respectively. The vagus nerve stimulator can generate the corresponding biphasic stimulation pulses after it receives stimulation parameters from the control App. When the transmitter power is 30 dBm and the distance between the transmitter coil and the receiver coil is 2 cm, the maximum electromagnetic coupling energy transmission efficiency reaches 15.4%. The detection accuracy of the coastline parameter algorithm is 88%. |
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| Keywords: | Keywords: epileptic EEG signal bio-signal preamplifier biphasic stimulation pulse generator electromagnetic coupling |
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