| 基于体素的形态学分析在脊髓损伤中的研究进展 |
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| 引用本文： | 包书圣,赵璨,,包星星,饶家声,.基于体素的形态学分析在脊髓损伤中的研究进展[J].中国医学物理学杂志,2021,0(9):1072-1076. |
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| 作者姓名： | 包书圣 赵璨 包星星 饶家声 |
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| 作者单位： | 1. 北京航空航天大学生物与医学工程学院生物材料与神经再生北京市重点实验室，北京100083；2. 中国康复科学所康复工程研究
所，北京100068；3. 首都医科大学康复医学院，北京100068；4. 北京航空航天大学生物医学工程高精尖创新中心，北京100083 |
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| 摘 要： | 创伤性脊髓损伤（SCI）通常会导致大脑皮质发生继发性损害，造成神经元凋亡或萎缩。基于体素的形态学（VBM）
技术凭借其无创性、精确性的优点，已在SCI患者大脑微观结构变化的研究中得到了广泛应用。本文主要从损伤后皮质
萎缩情况及其与患者临床表现间相关性的横向研究结果，损伤早期进行性神经退变的时空模式及其对患者临床结果预测
能力的纵向研究结果，损伤持续时间（亚急性、慢性等）、损伤严重程度（完全性、不完全性等）、临床康复情况（感觉运动功
能、神经性疼痛等）等因素对研究结果的不同影响这3个方面对VBM在SCI中的研究进展进行综述，并指出未来研究应进
一步提高VBM技术的可靠性，同时完善研究方案的设计，以促进VBM在脑功能探索和SCI康复治疗中的作用。
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| 关 键 词： | 脊髓损伤 脑结构 基于体素的形态学 综述 |
Advances in the research of spinal cord injury using voxel-based morphometry |
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| BAO Shusheng,ZHAO Can,,BAO Xingxing,RAO Jiasheng,.Advances in the research of spinal cord injury using voxel-based morphometry[J].Chinese Journal of Medical Physics,2021,0(9):1072-1076. |
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| Authors: | BAO Shusheng ZHAO Can BAO Xingxing RAO Jiasheng |
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| Affiliation: | 1.Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang
University, Beijing 100083, China 2. Institute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing 100068,
China 3. School of Rehabilitation, Capital Medical University, Beijing 100068, China 4. Beijing Advanced Innovation Center for Biomedical
Engineering, Beihang University, Beijing 100083, China |
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| Abstract: | Traumatic spinal cord injury (SCI) usually induces secondary damages to the cerebral cortex, leading to neuronal
apoptosis and atrophy. Voxel-based morphometry (VBM) has been widely applied in research of cerebral microstructural
alterations in SCI patients for its non-invasion and accuracy. Herein the advances in the research of SCI using VBM are
reviewed from 3 main aspects: (1) the cross-sectional study on post-injury cortical atrophy and its correlation with clinical
manifestations of patients, (2) the longitudinal study on the spatiotemporal pattern of progressive neurodegeneration in the
early stage after injury and its ability to predict the clinical outcomes, (3) the effects of disease duration (sub-acute, chronic,
etc.), injury severity (complete, incomplete, etc.) and clinical rehabilitation (sensory motor function, neuropathic pain, etc.)
on research results. The reliability of VBM technology and the design of research scheme should be further improved in
future researches for promoting the role of VBM in brain function exploration and SCI rehabilitation treatment. |
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| Keywords: | spinal cord injury brain structure voxel-based morphometry review |
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