The intrinsic resting state voice network in Parkinson's disease |
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| Authors: | Anneliese B. New Donald A. Robin Amy L. Parkinson Claudia R. Eickhoff Kathrin Reetz Felix Hoffstaedter Christian Mathys Martin Sudmeyer Jochen Michely Julian Caspers Christian Grefkes Charles R. Larson Loraine O. Ramig Peter T. Fox Simon B. Eickhoff |
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| Affiliation: | 1. University of Texas Health Science Center at San Antonio, Research Imaging Institute, San Antonio, Texas;2. University of Texas Health Science Center at San Antonio, Department of Neurology, San Antonio, Texas;3. University of Texas Health Science Center at San Antonio, Department of Radiology, San Antonio, Texas;4. University of Texas Health Science Center at San Antonio and University of Texas at San Antonio, Joint Program in Biomedical Engineering, San Antonio, Texas;5. Research Center Julich, Institute of Neuroscience and Medicine (INM‐1), Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital, Julich, Germany;6. University Hospital Aachen, Department of Psychiatry, Psychotherapy and Psychosomatics, Aachen, Germany;7. Department of Neurology, University of Aachen, Aachen, Germany;8. Research Center Julich, Institute of Neuroscience and Medicine (INM‐4), Department of Neurology, University Hospital, Julich, Germany;9. Julich Aachen Research Alliance, Translational Brain Medicine, Germany;10. Department of Clinical Neuroscience and Medical Psychology, Heinrich Heine University–Düsseldorf, Dusseldorf, Germany;11. Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, Dusseldorf, Germany;12. Department of Neurology, Heinrich Heine University – Dusseldorf, University Hospital, Dusseldorf, Germany;13. Department of Neurology, Cologne University, Cologne, Germany;14. Max‐Planck‐Institute for Neurological Research, Neuromodulation, and Neurorehabilitation, Cologne, Germany;15. Northwestern University, Communication Sciences and Disorders, Evanston, Illinois;16. Department of Speech, Language and Hearing Science, University of Colorado – Boulder, Colorado;17. National Center for Voice and Speech, Salt Lake City, Utah;18. South Texas Veterans Health Care System, Department of Neurology, San Antonio, Texas |
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| Abstract: | ![]()
Over 90 percent of patients with Parkinson's disease experience speech‐motor impairment, namely, hypokinetic dysarthria characterized by reduced pitch and loudness. Resting‐state functional connectivity analysis of blood oxygen level‐dependent functional magnetic resonance imaging is a useful measure of intrinsic neural functioning. We utilized resting‐state functional connectivity modeling to analyze the intrinsic connectivity in patients with Parkinson's disease within a vocalization network defined by a previous meta‐analysis of speech (Brown et al., 2009). Functional connectivity of this network was assessed in 56 patients with Parkinson's disease and 56 gender‐, age‐, and movement‐matched healthy controls. We also had item 5 and 18 of the UPDRS, and the PDQ‐39 Communication subscale available for correlation with the voice network connectivity strength in patients. The within‐group analyses of connectivity patterns demonstrated a lack of subcortical–cortical connectivity in patients with Parkinson's disease. At the cortical level, we found robust (homotopic) interhemispheric connectivity but only inconsistent evidence for many intrahemispheric connections. When directly contrasted to the control group, we found a significant reduction of connections between the left thalamus and putamen, and cortical motor areas, as well as reduced right superior temporal gyrus connectivity. Furthermore, most symptom measures correlated with right putamen, left cerebellum, left superior temporal gyrus, right premotor, and left Rolandic operculum connectivity in the voice network. The results reflect the importance of (right) subcortical nodes and the superior temporal gyrus in Parkinson's disease, enhancing our understanding of the neurobiological underpinnings of vocalization impairment in Parkinson's disease. Hum Brain Mapp 36:1951–1962, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. |
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| Keywords: | Parkinson's disease neuroimaging resting‐state functional connectivity voice network |
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