Peptidoglycan N-acetylglucosamine deacetylase,a putative virulence factor in Streptococcus pneumoniae |
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| Authors: | Vollmer Waldemar Tomasz Alexander |
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| Affiliation: | Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA. |
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| Abstract: | Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model. |
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