| ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值 |
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| 引用本文： | 范龙飞,吴斌全,庞青,汪鹿瑶,潘华东,王春芳,刘会春,谈燚.ALBI和PALBI分级在乙肝相关性肝细胞癌病人预后评估中的价值[J].蚌埠医学院学报,2023,48(3):330-334. |
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| 作者姓名： | 范龙飞 吴斌全 庞青 汪鹿瑶 潘华东 王春芳 刘会春 谈燚 |
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| 作者单位： | 蚌埠医学院第一附属医院 肝胆外科, 安徽 蚌埠 233004 |
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| 基金项目： | 蚌埠医学院自然科学研究重点项目BYKY1858ZD安徽省高校自然科学研究重点项目KJ2018ZD022国家级大学生创新创业训练项目201910367053 |
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| 摘 要： | 目的：探讨白蛋白-胆红素(ALBI)和血小板-白蛋白-胆红素(PALBI)分级在Child-Pugh A级肝细胞癌(HCC)病人预后评估中的价值。方法：行根治性手术的Child-Pugh A级乙肝相关性HCC病人134例，根据术前血清学检查结果计算ALBI和PALBI分级，采用Kaplan-Meier曲线和Cox回归分析评估病人总生存期(OS)和无复发生存期(RFS)。结果：经随访，病死37例，复发35例。Kaplan-Meier分析结果显示，ALBI、PALBI分级与OS和RFS均具有相关关系(P<0.05)。多因素分析显示，ALBI和PALBI分级均为病人独立的预后模型。不同评分系统间，PLABI+肿瘤直径、ALBI+肿瘤直径、ALBI+意大利肝癌小组评分(CLIP)较单独的CLIP、PLABI、ALBI、终末期肝癌模型评分、巴塞罗那分期在预后预测能力方面更具有意义。结论：ALBI和PALBI分级是评估Child-Pugh A级HCC病人预后有价值的模型，如结合肿瘤直径，PALBI较ALBI分级有更好的预后价值。
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| 关 键 词： | 肝细胞肿瘤 白蛋白-胆红素分级 血小板-白蛋白-胆红素分级 预后 |
| 收稿时间： | 2020-06-25 |
The value of ALBI and PALBI grades in the prognostic assessment of hepatitis B virus associated HCC patients |
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| Affiliation: | Department of Hepatobiliary Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China |
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| Abstract: | ObjectiveTo explore the value of albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grades in the prognostic evaluation of Child-Pugh grade A HCC patients.MethodsClinical data of 134 Child-Pugh grade A hepatitis B virus associated HCC patients undergoing radical resection were retrospectively analyzed.ALBI and PALBI grades were calculated based on preoperative serologic examination.Overall survival (OS) and recurrence-free survival (RFS) were estimated using Kaplan-Meier curves and Cox regression.ResultsAfter follow-up, 37 patients died and 35 patients relapsed.Kaplan-Meier analysis showed that ALBI and PALBI grades were significantly correlated with OS and RFS (P < 0.05).Multivariate analysis indicated that both ALBI and PALBI grades were independent prognostic models for patients.Among different scoring systems, PLABI + tumor diameter, ALBI + tumor diameter, and ALBI + Italian liver cancer group score (CLIP) were more significant in predicting prognosis than CLIP, PLABI, ALBI, end-stage liver cancer model score, and Barcelona staging alone.ConclusionsALBI and PALBI grades are valuable models for evaluating the prognosis of Child-Pugh grade A HCC patients, if when they combine with tumor diameter, PALBI grade has better prognostic value for HCC patients than ALBI grade. |
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