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| 肝硬化大鼠小肠微绒毛形态和超微结构的改变与肠源性内毒素血症的关系 | |
| 引用本文： | 任卫英,张顺财,涂传涛,周康.肝硬化大鼠小肠微绒毛形态和超微结构的改变与肠源性内毒素血症的关系[J].复旦学报(医学版),2008,35(1):125-127. |
| 作者姓名： | 任卫英 张顺财 涂传涛 周康 |
| 作者单位： | 1. 复旦大学附属中山医院老年科,上海,200032 2. 复旦大学附属中山医院消化科,上海,200032 3. 复旦大学附属中山医院中心实验室,上海,200032 |
| 摘 要： | 目的 观察肝硬化大鼠小肠黏膜形态及超微结构的改变与肠源性内毒素血症的关系.方法 CCl4诱导的肝硬化大鼠分为2组:肝硬化伴内毒素血症组(n=22)和肝硬化不伴内毒素血症组(n=18),另取20只健康大鼠作为正常对照组,分别观察小肠黏膜在光镜和电镜下的形态.结果 光镜下观察到肝硬化伴内毒素血症的大鼠小肠绒毛明显缩短,炎症细胞浸润明显;电镜下观察到肝硬化伴内毒素血症的大鼠小肠壁超微结构明显受损,紧密连接缺失,细胞间隙扩大,肝硬化不伴内毒素血症大鼠的小肠绒毛形态以及超微结构与正常大鼠相比没有明显改变.结论 肝硬化大鼠小肠黏膜损伤与肠源性内毒素血症的发生密切相关. |
| 关 键 词： | 肝硬化 肠源性内毒素血症 小肠黏膜形态 紧密连接 肝硬化 大鼠小肠 小肠微绒毛 小肠黏膜形态 超微结构 肠源性 内毒素血症 关系 rats endotoxemia small intestinal mucosa injury 相关 发生 黏膜损伤 正常大鼠 细胞间隙 紧密连接 肠壁 炎症细胞浸润 |
| 收稿时间： | 2007-06-01 |
| 修稿时间： | 2007年6月1日 |
The relationship between small intestinal mucosa injury and intestinal endotoxemia in cirrhotic rats |
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| REN Wei-ying,ZHANG Shun-cai,TU Chuan-tao,ZHOU Kang.The relationship between small intestinal mucosa injury and intestinal endotoxemia in cirrhotic rats[J].Fudan University Journal of Medical Sciences,2008,35(1):125-127. | |
| Authors: | REN Wei-ying ZHANG Shun-cai TU Chuan-tao ZHOU Kang |
| Abstract: | Objective To observe the relationship of intestinal mucosa injury and intestinal endotoxemia in cirrhotic rats. Methods Cirrhotic rats induced by CCl4 were divided into 2 groups:cirrhotic rats accompanied with intestinal endotoxemia (n=22) and cirrhotic rats without intestinal endotoxemia (n=18).Another 20 healthy rats were enrolled for normal controls group.The morphous of intestinal mucosa of all animals were observed under light microscope and electron microscope,respectively. Results In cirrhotic rats accompanied with intestinal endotoxemia,intestinal villi were injured under light microscopy.Electronic microscopy found microvilli and tight junction disappeared and intercellular space enlarged.But there were no obvious changes in cirrhotic rats without intestinal endotoxemia and normal rats. Conclusions The injury of intestinal mucosa may be closely correlated with intestinal endotoxemia in cirrhotic rats. |
| Keywords: | cirrhotic intestinal endotoxemia intestinal mucosa morphous tight junction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
