Modulation of Mycobacterium lepraemurium growth in murine macrophages: beneficial effect of tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor. |
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| Authors: | M Denis |
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| Affiliation: | Bioscience I, ICI Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire, United Kingdom. |
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| Abstract: | ![]()
Mycobacterium lepraemurium grew progressively in monolayers of Proteose Peptone-elicited macrophages from C57BL/6 mice. Treatment of macrophage monolayers with gamma interferon led to an enhancement of growth of M. lepraemurium in macrophages. Treatment with tumor necrosis factor alpha or granulocyte-macrophage colony-stimulating factor led to restriction of mycobacterial growth in macrophages. |
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