| 关节盘前移位对关节滑膜尿激酶型纤溶酶原激活剂及其1型抑制剂mRNA表达的影响 |
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| 引用本文： | 詹静,吴利群,谷志远,张银凯,胡济安.关节盘前移位对关节滑膜尿激酶型纤溶酶原激活剂及其1型抑制剂mRNA表达的影响[J].华西口腔医学杂志,2006,24(1):63-66. |
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| 作者姓名： | 詹静 吴利群 谷志远 张银凯 胡济安 |
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| 作者单位： | 浙江大学口腔医学院附属口腔医院,颌面外科,浙江,杭州,310006;浙江大学附属邵逸夫医院,牙科,浙江,杭州,310006;浙江大学口腔医学院附属口腔医院,口腔病理科,浙江,杭州,310006 |
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| 基金项目： | 中国科学院资助项目;浙江省新世纪151人才工程项目 |
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| 摘 要： | 目的 探讨关节盘前移位对滑膜中尿激酶型纤溶酶原激活剂（uPA）及其1型抑制剂（PAI-1）基因表达的影响。方法 40只日本大耳白兔, 在建立颞下颌关节盘前移位动物模型后，分别于术后4 d、1周、2周、4周、8周和12周处死，用原位杂交方法检测关节滑膜组织内uPA与PAI-1基因分布和表达变化。结果 正常滑膜中偶可见uPA和PAI-1染色弱阳性的滑膜内衬细胞，滑膜下层也可见少量成纤维细胞有uPA和PAI-1的弱阳性表达。术后1周，滑膜细胞及成纤维细胞中表达uPA和PAI-1阳性的细胞增加，其表达也逐渐增强，12周时，细胞中uPA和PAI-1的基因为强表达。结论 滑膜组织中存在较完善的uPA/PAI-1系统，该系统可能在由关节盘前移位造成的滑膜组织改变中起着重要的调节作用。
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| 关 键 词： | 尿激酶型纤溶酶原激活剂 纤溶酶原激活剂抑制剂-1 颞下颌关节 关节盘前移位 |
| 文章编号： | 1000-1182（2006）01-0063-04 |
| 收稿时间： | 2005-01-06 |
| 修稿时间： | 2005-05-20 |
Effect of Disc Displacement on mRNA Expression of Urokinase Plasminogen Activator and Its Inhibitor-1in Synovial Tissues |
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| ZHAN Jing,WU Li-qun,GU Zhi-yuan,ZHANG Yin-kai,HU Ji-an.Effect of Disc Displacement on mRNA Expression of Urokinase Plasminogen Activator and Its Inhibitor-1in Synovial Tissues[J].West China Journal of Stomatology,2006,24(1):63-66. |
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| Authors: | ZHAN Jing WU Li-qun GU Zhi-yuan ZHANG Yin-kai HU Ji-an |
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| Affiliation: | 1. Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Zhejiang University, Hangzhou 310006, China; 2. Dept. of Dentistry, Hospital of Sir Run Run Shaw, Zhejiang University, Hangzhou 310006, China; 3. Dept. of Oral Pathology, Hospital of Stomatology, Zhejiang University, Hangzhou 310006, China |
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| Abstract: | Objective To investigate the effect of anterior disc displacement on the expression of urokinase plasminogen activator and its inhibitor- 1 (uPA/PAI- 1) in synovial tissues. Methods Forty Japanese white rabbits were used in this study. The animals were killed at 4 days, 1, 2, 4, 8 and 12 weeks postoperatively, respectively. In situ hybridization technology was applied to detect the expression of uPA/PAI - 1 mRNA in synovial membrane. Results In normal synovial tissues, synovial lining cells and a few fibrosblasts with mild positive staining were occasionally seen. More synovial lining cells and fibrosblasts with moderate postive signals were found 1 week after operation. Since then, the degree of staining for uPA/PAI - 1 increased gradually. By the end of 12 weeks postoperatively, strong signals of uPA/PAI- 1 mRNA were detected. Conclusion There is a harmonized uPA/PAI- 1 system existing in synovial tissues. The high expression of uPA and PAI- 1 mRNA in synovial tissues indicates that the uPA/PAI - 1 system may play an important role in the process of synovitis resulted from anterior disc displacement. |
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| Keywords: | urokinase plasminogen activator plasminogen activator inhibitor-1 temporomandibular joint an-terior disc displacement |
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