| 面神经破冲复合伤模型的建立与研究 |
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| 引用本文： | 王彦亮,周树夏,雷德林,李兵仓,赖西南,张良潮. 面神经破冲复合伤模型的建立与研究[J]. 华西口腔医学杂志, 2003, 21(2): 95-97 |
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| 作者姓名： | 王彦亮 周树夏 雷德林 李兵仓 赖西南 张良潮 |
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| 作者单位： | 710032 第四军医大学口腔医院颌面外科(王彦亮,周树夏,雷德林),第三军医大学大坪医院野战外科研究所第六研究室 (李兵仓,赖西南,张良潮) |
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| 基金项目： | 军队“九五”规划指令性课题“颌面战伤救治”资助项目(编号 96L0 4 7) |
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| 摘 要： | 目的 建立一种模拟面神经爆炸伤的动物模型。方法 麻醉下在距犬面部5 cm、10 cm、15 cm处放置雷管模拟爆轰波致伤效应,并在雷管爆炸同时,用滑膛枪发射钢珠弹致犬同侧咬肌切线伤以模拟破片致伤。分别于伤后不同时间取动物心、肺、脑观察动物伤情,并检测面神经及其核团的病理改变,分析不同距离条件下全身和局部的创伤效应。结果 5 cm致伤时动物伤情较重,尤其是心肺脑等脏器损伤严重,不能存活较长时间;10 cm致伤时动物经过抢救仍可存活,受伤的面神经干肿胀,外膜不光滑,神经干内弥漫性出血;15 cm致伤时伤情较轻,局部神经的损伤程度随距伤道的距离增加而减轻,镜下表现为广泛的神经纤维断裂、坏死,同时神经元也变性、坏死, 并有大量炎细胞弥散浸润。结论 所建立的犬破冲复合伤模型重复性好,各项致伤条件可控,因此可作为研究面神经爆炸性损伤的动物实验模型。
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| 关 键 词： | 面神经 破冲复合伤 动物模型 |
| 收稿时间： | 2003-04-25 |
| 修稿时间： | 2001-05-22 |
Establishment of an Animal Model of Blast-fragment Combine Injury on Facial Nerve |
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| WANG Yanliang ,ZHOU Shuxia,LEI Delin,et al.. Establishment of an Animal Model of Blast-fragment Combine Injury on Facial Nerve[J]. West China journal of stomatology, 2003, 21(2): 95-97 |
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| Authors: | WANG Yanliang ZHOU Shuxia LEI Delin et al. |
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| Affiliation: | *Oral andMaxillofacialDepartment,Qin DuStomatological College,the Fourth MilitaryMedical University,Xi′an710032,China |
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| Abstract: | OBJECTIVE: This study was to establish an animal model to imitate facial nerves injury by explosion. METHODS: The impact was simulated by detonator blast in the distance of 5 cm, 10 cm and 15 cm over the face of dogs under anesthesia and the edge injury of masseters were made by rifle-shot steel ball to imitate segment injury in real explosion. The dogs were killed after different time of injury and the heart, lung, brain and facial nerve were taken to observe the pathological changes in order to evaluating the wound effect in different distances. RESULTS: The animal was injured severely in the distance of 5 cm and could not survive for a long time because of severe damage to brain, heart and lung. The dogs injured at 10 cm could survive after emergency treatment, and there was diffusing hemorrhage in edematous nerve trunk. In the distance of 15 cm, the dogs were injured slightly and, as the distance to the explosive source increased, the local wound became slighter. Under light microscope, the breakage and necrosis of facial nerve fibers could be widely observed, degenerative and necrotic neurons with infiltrating inflammatory cells could be found in the facial nerve nuclei as well. CONCLUSION: The dog's traumatic model established by impact wave and segment in this experiment is an appropriate animal model for the research of explosive effect on facial nerves because of its controllable and repeatable injuring conditions. |
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| Keywords: | facial nerve injury of explosion animal model |
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