PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice |
| |
| Authors: | Holder I A Neely A N Frank D W |
| |
| Affiliation: | Department of Microbiology, Shriners Hospital for Children, Cincinnati, Ohio 45229, USA. iaholder@juno.com |
| |
| Abstract: | ![]()
Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
