| 治疗前纤维蛋白原联合中性粒细胞淋巴细胞比值对鼻咽癌调强放疗患者预后的预测价值 |
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| 引用本文： | 王颖熠,党倩倩,邓小玉,陈林会,李冰妍,李慧珍,周鹏程,梁天嵩,' target='_blank'>,郑颖娟,' target='_blank'>,杨道科,' target='_blank'>.治疗前纤维蛋白原联合中性粒细胞淋巴细胞比值对鼻咽癌调强放疗患者预后的预测价值[J].现代肿瘤医学,2023,0(9):1646-1653. |
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| 作者姓名： | 王颖熠 党倩倩 邓小玉 陈林会 李冰妍 李慧珍 周鹏程 梁天嵩 ' target='_blank'> 郑颖娟 ' target='_blank'> 杨道科 ' target='_blank'> |
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| 作者单位： | 1.郑州大学第一附属医院放疗科，河南 郑州 450000；2.郑州大学放疗与肿瘤急危重症研究所，河南 郑州 450000 |
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| 基金项目： | 河南省医学科技攻关计划联合共建项目（编号:LHGJ20190046） |
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| 摘 要： | 目的:探讨治疗前纤维蛋白原（Fib）与中性粒细胞淋巴细胞比值（NLR）的联合指标（F-NLR评分）在接受调强放射治疗（IMRT）的鼻咽癌（NPC）患者中的预后价值。方法:回顾性分析我院放疗科2016年1月至2018年12月收治的接受IMRT的NPC患者的临床资料。根据受试者工作特征曲线计算Fib及NLR的最佳截断值，并对患者进行分组。采用χ2检验或Fisher确切概率法比较不同分组间临床特征和近期疗效的差异。运用Cox比例风险模型进行单因素和多因素生存分析，探讨影响预后的风险因素。通过Kaplan-Meier法绘制生存曲线，采用Log-rank法比较各组生存曲线的差异。P＜0.05为差异具有统计学意义。结果:Fib和NLR的最佳截断值分别为3.455 g/L和2.99。不同F-NLR分组的饮酒和T分期存在显著差异。不同Fib、NLR和F-NLR分组的近期疗效存在显著差异。多因素分析显示F-NLR评分、TNM分期和EBV DNA拷贝数是影响NPC患者OS的独立危险因素。不同F-NLR分组的OS和PFS生存曲线两两之间存在显著差异(P＜0.001)。结论:治疗前高F-NLR评分是接受IMRT的NPC患者的独立预后不良因素，联合TNM分期和EBV DNA拷贝数可更加准确预测鼻咽癌患者预后。
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| 关 键 词： | 鼻咽癌 纤维蛋白原 中性粒细胞淋巴细胞比值 预后 |
Prognostic value of fibrinogen combined with neutrophil-lymphocyte ratio in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy before treatment |
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| WANG Yingyi,DANG Qianqian,DENG Xiaoyu,CHEN Linhui,LI Bingyan,LI Huizhen,ZHOU Pengcheng,LIANG Tiansong,' target='_blank'>,ZHENG Yingjuan,' target='_blank'>,YANG Daoke,' target='_blank'>.Prognostic value of fibrinogen combined with neutrophil-lymphocyte ratio in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy before treatment[J].Journal of Modern Oncology,2023,0(9):1646-1653. |
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| Authors: | WANG Yingyi DANG Qianqian DENG Xiaoyu CHEN Linhui LI Bingyan LI Huizhen ZHOU Pengcheng LIANG Tiansong ' target='_blank'> ZHENG Yingjuan ' target='_blank'> YANG Daoke ' target='_blank'> |
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| Affiliation: | 1.Radiotherapy Department,the First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450000,China;2.Institute of Radiation Therapy and Oncology Emergency Critical Care，Zhengzhou University,Henan Zhengzhou 450000,China. |
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| Abstract: | Objective: To investigate the prognostic value of fibrinogen (Fib) combined with neutrophil-lymphocyte ratio (NLR) index (F-NLR score) before intensity-modulated radiation therapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).Methods:The clinical data of NPC patients who received IMRT between January 2016 and December 2018 were retrospectively analyzed.The optimal cut-off values of Fib and NLR were calculated according to the receiver operating characteristic curve,after which the patients were grouped.Differences in clinical characteristics and the short-term efficacy of treatment between the groups were analyzed using χ2 or Fisher's exact tests.Univariate and multivariate survival analyses were performed using the Cox proportional hazards model to identify the risk factors affecting prognosis.The survival curves were drawn by the Kaplan-Meier method,and Log-rank tests were used to compare the differences between the survival curves of each group.P<0.05 was considered statistically significant.Results:The optimal cut-off values of Fib and NLR were 3.455 g/L and 2.99,respectively.Significant differences were found for alcohol consumption and T stage between the F-NLR groups.There were also significant differences in the short-term efficacy of treatment in the different Fib,NLR,and F-NLR groups.Multivariate analysis showed that the F-NLR score,TNM stage,and EBV DNA copy number were independent risk factors for overall survival in NPC patients and both overall and progression-free survival differed significantly between the different F-NLR groups (P<0.001).Conclusion:High F-NLR score before treatment is an independent risk factor for poor prognosis in NPC patients receiving IMRT,and the combination of TNM stage and EBV DNA copy number can more accurately predict the prognosis of NPC patients. |
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| Keywords: | nasopharyngeal carcinoma fibrinogen neutrophil-lymphocyte ratio prognosis |
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