| 嗜铬细胞瘤/副神经节瘤骨转移临床特征及危险因素分析 |
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| 引用本文： | 李隆敏,高洪波,李 赟,李 征,刘海春,张晓勇,邵玉军.嗜铬细胞瘤/副神经节瘤骨转移临床特征及危险因素分析[J].现代肿瘤医学,2023,0(2):332-336. |
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| 作者姓名： | 李隆敏 高洪波 李 赟 李 征 刘海春 张晓勇 邵玉军 |
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| 作者单位： | 北京核工业医院核素诊疗中心，北京 102413 |
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| 基金项目： | 北京核工业医院院长基金（编号:YZJJ-2018-005）；中国宝原科研基金（编号:ZGBYKYJJ-2021-002） |
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| 摘 要： | 目的:探讨嗜铬细胞瘤/副神经节瘤（pheochromocytoma/paraganglioma，PPGLs）术后骨转移患者的临床特征及早期（术后2年内）发生骨转移的危险因素。方法:收集60例初诊为PPGLs术后骨转移患者的临床资料并分析骨转移的危险因素及骨转移灶的分布差异。结果:60 例PPGLs患者单发骨转移14 例（23.3%），多发者46 例（76.7%）。发生骨转移的中位时间为 84 个月，早期骨转移者 15 例（25%）。单因素分析示PPGLs患者的年龄与早期骨转移有关（χ2=6.207，P=0.045）。早期骨转移中年龄＜60岁者多见，差异有统计学意义（χ2=25.600，P=0.000）。PPGLs共发现骨转移灶 353处，其中胸椎转移 79 处。27例（45.0%）患者出现骨转移相关并发症，依次为骨痛（88.9%）、麻木（51.9%）、骨折（37.0%）、瘫痪（11.1%）及高钙血症（3.7%）。结论:PPGLs患者的年龄与早期骨转移有关，年龄＜60岁者发生早期骨转移多见，绝大多数骨转移发生在手术 2年以后。PPGLs骨转移灶通常为多发，其中以胸椎转移最为常见。骨转移相关并发症最常见为骨痛。
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| 关 键 词： | 嗜铬细胞瘤 副神经节瘤 骨转移 临床特征 危险因素 |
Clinical characteristics and risk factors of PPGL patients with bone metastases |
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| LI Longmin,GAO Hongbo,LI Yun,LI Zheng,LIU Haichun,ZHANG Xiaoyong,SHAO Yujun.Clinical characteristics and risk factors of PPGL patients with bone metastases[J].Journal of Modern Oncology,2023,0(2):332-336. |
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| Authors: | LI Longmin GAO Hongbo LI Yun LI Zheng LIU Haichun ZHANG Xiaoyong SHAO Yujun |
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| Affiliation: | Department of Radionuclide Treatment Center,Beijing Nuclear Industry Hospital,Beijing 102413,China. |
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| Abstract: | Objective:To explore the clinical characteristics of PPGLs with bone metastasisand the risk factors of earlybone metastasis（withinpostoperative 2 years）.Methods:The clinical data of 60 PPGL patients with bone metastasiswere analysedretrospectively.The risk factors and distribution differences of bonemetastasiswere analyzed.Results:Among 60 PPGL patients,14 cases(23.3%)had single bone metastasis and 46 cases(76.7%)hadmultiple bone metastases.The median time of bone metastasis was 84 months,and 15 cases(25%)had early bone metastasis.Univariate analysis showed that the age of PPGL patients was correlated with the time of bone metastasis(χ2=6.207,P=0.045).Early bone metastasis was more common in patients younger than 60 years old,the difference was statistically significant(χ2=25.600,P=0.000).A total of 353 lesions of bone metastases were found in PPGLs,including 79 lesions of thoracic vertebras.27 cases(45.0%)had complications related to bone metastasis,followed by bone pain(88.9%),numbness(51.9%),fracture(37.0%),paralysis(11.1%)and hypercalcemia(3.7%).Conclusion:Early bone metastasis is more common in patients younger than 60 years.Most bone metastasis occurs after two years of operation.Bone metastasis of PPGLsis usually multiple,of which the thoracic vertebra is the most frequent region.The most common complication is bone pain. |
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| Keywords: | pheochromocytoma paraganglioma bone metastasis clinical features risk factors |
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