| 颞下颌关节骨关节病髁突组织细胞凋亡的研究 |
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| 引用本文： | 常嘉,马绪臣,武登诚,焦岩涛.颞下颌关节骨关节病髁突组织细胞凋亡的研究[J].华西口腔医学杂志,2004,22(5):353-356. |
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| 作者姓名： | 常嘉 马绪臣 武登诚 焦岩涛 |
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| 作者单位： | 北京大学口腔医院,颞下颌关节病及口颌面痛诊治中心,北京,100081;北京大学口腔医院,外科实验室,北京,100081;北京大学口腔医院,综合科,北京,100081 |
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| 基金项目： | 国家自然科学基金资助项目(30171015) |
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| 摘 要： | 目的研究颞下颌关节骨关节病骸突组织中软骨细胞凋亡发生的特点,探讨细胞凋亡在颞下颌关节骨关节病发病机制中的作用。方法通过手术切除部分关节盘的方法建立颞下颌关节骨关节病动物模型,15 d-6个月内采用TUNEL法标记裸突各相应时段的凋亡细胞,结合相应组织学变化,观察、分析颞下颌关节骨关节病裸突组织中细胞凋亡发生的特点。结果关节盘损伤后软骨产生明显应激性修复增殖反应时,凋亡细胞主要集中于关节表面的纤维层中;随着关节软骨和骨组织不断改建,软骨组织中逐渐出现大量的细胞凋亡现象,主要发生于表面纤维层与增殖层,尤其集中在软骨细胞簇中;在软骨组织消耗严重时,浅表区域内的细胞凋亡现象逐渐减少,肥大钙化层中出现了较多的凋亡细胞。结论颞下颌关节骨关节病骸突软骨组织中存在过量凋亡的现象,软骨细胞异常增殖与过度凋亡导致软骨基质自身调节机制的破坏可能是骨关节病发生的重要原因之一。
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| 关 键 词： | 颞下颌关节 骨关节病 细胞凋亡 |
| 文章编号： | 1000-1182(2004)05-0353-04 |
| 收稿时间： | 2004-10-25 |
| 修稿时间： | 2004年6月3日 |
Study on the Characteristics of Apoptosis in the Condyles of Osteoarthritic Temporomandibular Joints |
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| CHANG Jia,MAXu-chen,WU Deng-cheng,JIAO Fare-tao ..Study on the Characteristics of Apoptosis in the Condyles of Osteoarthritic Temporomandibular Joints[J].West China Journal of Stomatology,2004,22(5):353-356. |
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| Authors: | CHANG Jia MAXu-chen WU Deng-cheng JIAO Fare-tao |
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| Affiliation: | 1.Center for Temporomandibular Joints Disorders and Orofacial Pain, School of Stomatology, Peking University; 2. Laboratory of Oral Maxillofacial Surgery, School of Stomatology, Peking University; 3. Dept.of Integrated, School of Stomatology, Peking University, Beijing 100081,China |
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| Abstract: | Objective To study the characteristics of apoptosis in the condyles of osteoarthritic temporomandibular joints, and investigate its role in the pathogenesis of the disease. Methods Temporomandibular joint osteoarthrosis model of rabbits was created by partial resection of joint disc. The animal models were sacrificed in the 15th day, the 1st month, the 2nd month, the 3rd month, the 4 month, the 5 month, and the 6 month chronologically. Then the pathological condyles were sectioned and detected with TUNEL method to investigate the apoptosis within the tissue. Results In the reactive repairing state of osteoarthrosis, the apoptosis cells mainly located in the superficial fibrous layer of articular cartilage. With the remodeling of articular cartilage and bone, the apoptosis cells gradually appeared in the proliferating layer, especially in the "clusters of chondrocytes". Accompanied with the severe damage and lose of articular cartilage, the phenomena of apoptosis decreased in the lower zone of cartilage and increased in the hypertrophic and calcified zone. Conclusion There were abundant phenomena of apoptosis within the condylar cartilage of osteoarthritic temporomandibular joint. Abnormal proliferation and abundant apoptosis would disturb the regulation mechanism in the cartilage matrix and lead to the osteoarthrosis. |
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| Keywords: | temporomandibular joint osteoarthrosis apoptosis |
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