|
|||||
|
|
| 血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系 | |
| 引用本文： | 汪琼,金国玺,于磊. 血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与2型糖尿病肾病的关系[J]. 蚌埠医学院学报, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009 |
| 作者姓名： | 汪琼 金国玺 于磊 |
| 作者单位： | 蚌埠医学院第一附属医院 内分泌科, 安徽 蚌埠 233004 |
| 摘 要： | 目的:测定血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGF-BP3)水平,探讨其与2型糖尿病肾病的关系。方法:选择2型糖尿病患者86例,根据其尿微量白蛋白排泄率(UAER)结果分为单纯糖尿病组(SDM组)33例、早期糖尿病肾病组(EDN组)28例和临床期肾病组(CDN组)25例。检测IGF-1、IGF-BP3、UAER等指标,分析IGF-1、IGF-BP3与糖尿病肾病的发病和病情轻重的关系。结果:CDN组血清IGF-1、IGF-BP3和UAER均明显高于SDM与EDN组(P <0.01),CDN组血清IGF-1、IGF-BP3和UAER亦均明显高于EDN组(P <0.01)。 IGF-1与肌酐、尿素氮、UAER和IGF-BP3均呈正相关关系(P <0.01),与年龄和糖化血红蛋白均无相关关系(P >0.05),而与空腹血糖呈负相关关系(P <0.01)。结论:血清IGF-1、IGF-BP3水平与2型糖尿病肾病的发生发展有相关性,可作为糖尿病肾病早期的诊断指标之一。 |
| 关 键 词： | 糖尿病肾病 胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 |
| 收稿时间： | 2014-11-11 |
The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy |
|
| WANG Qiong,JIN Guo-xi,YU Lei. The correlation of the serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the type 2 diabetic nephropathy[J]. Journal of Bengbu Medical College, 2016, 41(5): 586-588. DOI: 10.13898/j.cnki.issn.1000-2200.2016.05.009 | |
| Authors: | WANG Qiong JIN Guo-xi YU Lei |
| Affiliation: | Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China |
| Abstract: | Objective:To measure the serum levels of insulin-like growth factor-1 ( IGF-1 ) and insulin-like growth factor binding protein-3( IGF-BP3 ) in patients with type 2 diabetic nephropathy, and explore its correlation with type 2 diabetic nephropathy. Methods:According to the results of the urinary albumin excretion rate( UAER) ,86 patients with type 2 diabetes were divided into the simple diabetes group ( SDM group, 33 cases ) , early diabetic nephropathy group ( EDN group, 28 cases ) and clinical stage of nephropathy group(CDN group,25 cases). The levels of the IGF-1,IGF-BP3,UAER and other indicators were detected,which was used to analyze the correlations of IGF-1 and IGF-BP3 with diabetic nephropathy. Results:The serum levels of IGF-1 and IGF-BP3 and UAER in CDN group were higher than those in SDM group and CDN group(P<0. 01),the serum levels of IGF-1,IGF-BP3 and UAER in CDN group were higher than those in EDN group(P<0. 01). The IGF-1 was positive correlation with the creatinine,urea nitrogen, UAER and IGF-BP3,respectively(P<0. 01),the IGF-1 was correlation without age and glycosylated hemoglobin(P>0. 05),and was negative correlation with fasting plasma glucose(P<0. 01). Conclusions:The serum levels of IGF-1 and IGF-BP3 are related to the occurrence and development of type 2 diabetic nephropathy, which can be used as one of the early diagnosis index of diabetic nephropathy. |
| Keywords: | nephropathy insulin-like growth factor-1 insulin-like growth factor binding protein-3 |
| 本文献已被 万方数据 等数据库收录！ | |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 | |
| 点击此处可从《蚌埠医学院学报》下载免费的PDF全文 | |