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| 靶向血管生成拟态治疗肿瘤的研究进展 | |
| 引用本文： | 李富荣,程先硕,李云峰. 靶向血管生成拟态治疗肿瘤的研究进展[J]. 实用肿瘤学杂志, 2015, 29(4): 359-363. DOI: 10.11904/j.issn.1002-3070.2015.04.016 |
| 作者姓名： | 李富荣 程先硕 李云峰 |
| 作者单位： | 昆明医科大学第三附属医院(云南省肿瘤医院)大肠癌临床研究中心(昆明 650118) |
| 基金项目： | 国家自然科学基金资助项目(30960455);云南省卫生厅-昆明医科大学联合专项(2013FB166;2012FB071) |
| 摘 要： | 肿瘤微血管包括由血管内皮细胞围成的经典血管结构和由肿瘤细胞围成的血管生成拟态(Vasculogenic mimicry,VM)两种模式。近年研究提示,抗血管生成药能够显著抑制经典的微血管结构,但是不能抑制VM形成,反而促进VM形成。这是影响其临床疗效的原因之一。然而近期研究发现,中成药、基因治疗以及其它靶向VM形成机制的药在抗VM形成中具有独特的优势。本文就目前靶向VM形成治疗肿瘤的研究现状展开综述,为开发既能抗血管生成又能抗VM形成的新一代抗血管生成药提供借鉴。 |
| 关 键 词： | 血管生成拟态 肿瘤治疗 抗血管生成 |
| 收稿时间： | 2015-03-29 |
Advances in cancer therapy by targeting vasculogenic mimicry |
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| LI Furong,CHENG Xianshuo,LI Yunfeng. Advances in cancer therapy by targeting vasculogenic mimicry[J]. Journal of Practical Oncology, 2015, 29(4): 359-363. DOI: 10.11904/j.issn.1002-3070.2015.04.016 | |
| Authors: | LI Furong CHENG Xianshuo LI Yunfeng |
| Affiliation: | Clinical Research Center of Colorectal Cancer,The Third Affiliated Hospital of Kunming Medical University,Tumor Hospital of Yunnan Province,Kunming 650118,China |
| Abstract: | Tumor microvessel including two modes,as one is classic vascular structures surrounded with vascular endothelial cells and the other is vasculogenic mimicry(VM)surrounded with cancer cells.Recent studies suggested that anti-angiogenic drugs can inhibit classic microvessel structure significantly,but can not inhibit VM formation and even promote VM formation further more.This is one of the reasons affecting its clinical efficacy.However,basic research has shown that traditional chinese medicine,gene therapy and drugs which is targeting for VM formation have an unique advantage in anti-VM.In this review,we summarize the progress of cancer therapy on targeting vasculogenic mimicry,and provide a basic for the development of new drugs for cancer therapy through targeting both angiogenesis and VM formation. |
| Keywords: | Vasculogenic mimicry Cancer therapy Antiangiogenic |
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