| 容积旋转调强放疗中射野等中心选择对宫颈癌剂量学的影响 |
| |
| 引用本文： | 邓佳,吴湘阳,常晓斌,张坤,何耀东,赵强.容积旋转调强放疗中射野等中心选择对宫颈癌剂量学的影响[J].现代肿瘤医学,2022,0(1):101-106. |
| |
| 作者姓名： | 邓佳 吴湘阳 常晓斌 张坤 何耀东 赵强 |
| |
| 作者单位： | 1.陕西省肿瘤医院放疗科,陕西 西安 710061;
2.西安交通大学核科学与技术学院，陕西 西安 710049 |
| |
| 基金项目： | 陕西省重点研发新计划项目(编号:2010KTZDSF02-03)。 |
| |
| 摘 要： | 目的:采用容积旋转调强技术设计放疗计划，选择不同的射野等中心进行优化，讨论射野等中心的改变对宫颈癌容积旋转调强放疗剂量学的影响。方法:随机选取宫颈癌术后患者15例，在同一套CT图像上设计不同的VMAT计划，根据宫颈癌病例靶区几何形状特点，选择不同等中心位置制定四组不同计划，分别为:计划等中心为靶区几何中心，称为Center计划；计划等中心为靶区几何中心y方向上移9 cm，称为Y计划，计划等中心为靶区几何中心x方向左移7 cm，称为X计划，计划靶区几何中心y方向上移9 cm再向x方向左移7 cm，称为X-Y计划。比较分析四种方案的靶区及危及器官的剂量学参数。结果:Center和Y计划能够满足临床靶区及危及器官限量。相较于Center计划， Y、X、X-Y计划靶区覆盖率分别降低了0.36%、15.48%和6.52%；Y计划的适形度指数（CI）、均匀性指数（HI）、脊髓的Dmax、膀胱的V40、直肠的V40均优于 X计划和X-Y计划，差异具有统计学意义（P＜0.05）。结论:宫颈癌术后病例的VMAT计划设计中，使用不同等中心设计计划，与等中心位置在几何中心相比，向y轴方向偏移，对靶区和危及器官的影响较小，变化范围在临床可接受范围之内；而等中心位置向x轴方向偏移，对靶区和危及器官影响较大。
|
| 关 键 词： | 宫颈癌 射野等中心 容积旋转调强 剂量学 |
The dosimetry effect of the different positions of isocenter for volumetric modulated arc therapy treatment of cervical cancer |
| |
| DENG Jia,WU Xiangyang,CHANG Xiaobin,ZHANG Kun,HE Yaodong,ZHAO Qiang.The dosimetry effect of the different positions of isocenter for volumetric modulated arc therapy treatment of cervical cancer[J].Journal of Modern Oncology,2022,0(1):101-106. |
| |
| Authors: | DENG Jia WU Xiangyang CHANG Xiaobin ZHANG Kun HE Yaodong ZHAO Qiang |
| |
| Affiliation: | 1.Department of Radiation Oncology，Shaanxi Province Cancer Hospital，Shaanxi Xi'an 710061,China;2.School of Nuclear Science and Technology,Xi'an Jiaotong University,Shaanxi Xi'an 710049,China. |
| |
| Abstract: | Objective:To quantify the impact of the different positions of isocenter for volumetric modulated arc therapy treatment of postoperative cervical cancer cervical cancer.Methods:Fifteen patients receiving postoperative radiotherapy for cervical cancer were selected.According to different position of isocenter,four VMAT plans were disigned on the same CT image,including Center plan,Y plan,X plan and X-Y plan.The position of isocenter had been distributed in 4 positions:symmetry center of the target(Center plan),9 cm up in the Y direction of the symmetry center(Y plan),7 cm to the left in the X direction of the symmetry center(X plan),9 cm up in the Y direction and 7 cm to the left in the X direction of the symmetry center(X-Y plan).The conformity index and homogeneity index of target areas,dosimetric differences of organs-at-risk and monitor units were compared.Results:The center plan and Y plan were satisfied with the clinical requirements.Compared with the center plan,the target coverage of the Y,X and X-Y plans decreased by 0.36%,15.48%and 6.52%,respectively.Compared with X plan and X-Y plan,conformity index(CI),uniformity index(HI),the Dmax of spinal cord,the V40 of bladder,the V40 of the rectem were better in Y plan,with statistical significance(P<0.05).Conclusion:In the design of the VMAT plan for postoperative cases of cervical cancer,the isocenter position is offset from the y-axis,which is suitable for clinical application.However,the isocenter position is offset in the x-axis direction,which is not suitable for clinical application because the OAR is at higher dose. |
| |
| Keywords: | cervical cancer isocenter optimization volumetric modulated arc therapy dosimetry |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载全文 |
|
