Long‐term outcome of renal transplantation from octogenarian donors: A multicenter controlled study |
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| Authors: | Piero Ruggenenti Cristina Silvestre Luigino Boschiero Giovanni Rota Lucrezia Furian Annalisa Perna Giuseppe Rossini Giuseppe Remuzzi Paolo Rigotti |
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| Affiliation: | 1. IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, Bergamo, Italy;2. Nephrology and Dialysis Unit, Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII, Bergamo, Italy;3. Kidney and Pancreas Transplant Unit, University Hospital of Padua, Padua, Italy;4. Kidney Transplantation Unit, Department of Surgery, Azienda Ospedaliero‐Universitaria (AOUI) di Verona, Verona, Italy;5. Kidney Transplantation Center, Unit of Pediatric Surgery, Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII, Bergamo, Italy;6. Organ and Tissue Transplant Immunology Unit, Foundation IRCCS “Ca’ Granda Ospedale Maggiore Policlinico”, Milan, Italy;7. Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy |
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| Abstract: | ![]()
To assess whether biopsy‐guided selection of kidneys from very old brain‐dead donors enables more successful transplantations, the authors of this multicenter, observational study compared graft survival between 37 recipients of 1 or 2 histologically evaluated kidneys from donors older than 80 years and 198 reference‐recipients of non–histologically evaluated single grafts from donors aged 60 years and younger (transplantation period: 2006‐2013 at 3 Italian centers). During a median (interquartile range) of 25 (13‐42) months, 2 recipients (5.4%) and 10 reference‐recipients (5.1%) required dialysis (crude and donor age‐ and sex‐adjusted hazard ratio [95% confidence interval] 1.55 [0.34‐7.12], P = .576 and 1.41 [0.10‐19.54], P = .798, respectively). Shared frailty analyses confirmed similar outcomes in a 1:2 propensity score study comparing recipients with 74 reference‐recipients matched by center, year, donor, and recipient sex and age. Serum creatinine was similar across groups during 84‐month follow‐up. Recipients had remarkably shorter waiting times than did reference‐recipients and matched reference‐recipients (7.5 [4.0‐19.5] vs 36 [19‐56] and 40 [24‐56] months, respectively, P < .0001 for both comparisons). Mean (± SD) kidney donor risk index was 2.57 ± 0.32 in recipients vs 1.09 ± 0.24 and 1.14 ± 0.24 in reference‐recipients and matched reference‐recipients (P < .0001 for both comparisons). Adverse events were similar across groups. Biopsy‐guided allocation of kidneys from octogenarian donors permits further expansion of the donor organ pool and faster access to a kidney transplant, without increasing the risk of premature graft failure. |
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| Keywords: | clinical research/practice clinical trial donors and donation: donor evaluation graft survival kidney transplantation/nephrology organ allocation organ procurement organ procurement and allocation pathology/histopathology |
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