Anaplastic large cell lymphoma involving the urinary bladder: A case report and review of the literature |
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| Authors: | Haiyan Chen M.D. Ph.D. Yanxia Li M.D. Ph.D. Sucha Nand M.D. Marcus L. Quek M.D. Ameet R. Kini M.D. Ph.D. Güliz A. Barkan M.D. |
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| Affiliation: | 1. Department of Pathology, Loyola University Medical Center, Maywood, Illinois;2. Department of Medicine, Loyola University Medical Center, Maywood, Illinois;3. Department of Urology, Loyola University Medical Center, Maywood, Illinois |
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| Abstract: | T cell‐derived malignant lymphoma is rarely detected as a bladder neoplasm. A literature review for anaplastic large cell lymphoma (ALCL) involving urinary bladder reveals only seven previously reported cases. Here, we report a case of a 59‐year‐old HIV‐negative man with ALK‐positive ALCL. He presented an unusual clinical course with initial consideration of adult onset Still's Disease (AOSD) due to his negative results searching for malignancy and infectious diseases. He rapidly developed macrophage activation (hemophagocytic) syndrome and experienced an unusual rapid disease progression and died in 39 days after onset of symptoms. Compared to previously reported cases, the current case of ALK‐1‐positive ALCL is a rare case with an unusual presentation. From this case, we learned that ALCL is one malignancy that should be considered and screened in patients with suspected AOSD. Also, T‐cell lymphoma associated hemophagocytic syndrome should be considered in a patient with sustained corticosteroid‐resistant spike fever, high serum ferritin, and rapid exacerbation of the disease course. Diagn. Cytopathol. 2015;43:60–65. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | anaplastic large cell lymphoma anaplastic lymphoma kinase urinary bladder T‐cell lymphoma‐associated hemophagocytic syndrome |
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