Elevated thyroid stimulating hormone levels are associated withmetabolic syndrome in a Chinese community-based populationof euthyroid people aged 40 years and older |
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| Authors: | Bojin Xu Hui Yang Zhixiao Wang Tao Yang Hongwei Guo Pei Cheng Wei He Min Sun Huanhuan Chen Yu Duan |
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| Affiliation: | Department of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China |
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| Abstract: | This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome ineuthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40–77 yearsold) with TSH levels in the normal range (0.35–5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level withinthe normal range, we divided subjects into the high-TSH (2.50–5.00 mU/L; n = 1,064) and low-TSH (0.35–2.50mU/L; n = 1,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC),low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH groupand TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG. The prevalence of centralobesity, hypertriglyceridemia, low high density lipoprotein cholesterol (HDL-C), and high FPG (>5.60 mmol/L) wassignificantly higher in females and subjects with high-TSH levels. Metabolic syndrome was also more prevalent in thehigh-TSH group. People over the age of 40 years with high-normal TSH levels had a 1.2-fold increased risk ofmetabolic syndrome, compared with those with low-normal TSH levels, after adjusting for age and gender. Inconclusion, high normal TSH is a risk factor for metabolic syndrome in people≥40 years old. |
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| Keywords: | thyroid stimulating hormone euthyroid metabolic syndrome central obesity dyslipidemia |
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