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| 长链非编码RNA HOTAIR在膀胱癌中的表达及临床意义 | |
| 引用本文： | 李 宁,马 骏. 长链非编码RNA HOTAIR在膀胱癌中的表达及临床意义[J]. 天津医科大学学报, 2016, 0(2): 126-128 |
| 作者姓名： | 李 宁 马 骏 |
| 作者单位： | （天津医科大学公共卫生学院流行病与卫生统计学系，天津 300070） |
| 摘 要： | 目的: 探讨长链非编码RNA HOTAIR在膀胱癌组织与癌旁正常组织的表达差异，了解HOTAIR与膀胱癌恶性程度、进展及预后的相关性。方法: 采用qRT-PCR方法检测88例膀胱癌组织与癌旁正常组织中HOTAIR RNA的差异表达，分析HOTAIR表达水平与患者临床病理特征的关系，采用Kapaln-Meier生存分析及COX 比例风险回归模型分析HOTAIR表达水平与膀胱患者预后的相关性。结果: 膀胱癌组织中HOTAIR RNA 表达明显高于癌旁正常组织，HOTAIR RNA高表达与肿瘤高分级及临床高分期有关（P<0.05），HOTAIR高表达组膀胱癌患者5年生存率明显低于HOTAIR低表达组（P<0.05），COX 回归分析提示HOTAIR RNA高表达可能为膀胱癌不良预后的独立危险因子之一。结论: 长链非编码RNA HOTAIR与膀胱癌发生发展及其恶性程度相关，HOTAIR可以作为预测膀胱癌患者生存率的分子标志物。 |
| 关 键 词： | 长链非编码RNA HOTAIR 膀胱癌 |
Clinical significance of HOTAIR expression in patients with bladder cancer |
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| LI Ning,MA Jun.. Clinical significance of HOTAIR expression in patients with bladder cancer[J]. Journal of Tianjin Medical University, 2016, 0(2): 126-128 | |
| Authors: | LI Ning MA Jun. |
| Affiliation: | (Department of Epidemiology and Health Statistics, School of Public Health, Tianjin Medical University, Tianjin 300070,China) |
| Abstract: | Objective: To investigate the HOTAIR expression in bladder cancer tissues and adjacent non-cancerous tissues and its potential relevance to clinicopathological variables and prognosis. Methods: HOTAIR RNA expression was determined by real-time quantitative polymerase chain reaction in 88 pairs of bladder cancer tissues and adjacent non-cancerous tissues. Kapaln-Meier analysis and COX proportional hazards regression models were used to investigate the correlation between HOTAIR expression and prognosis of bladder cancer patients. Results: This study showed that the expression level of HOTAIR in bladder cancer tissues was significantly higher than those in non-cancerous tissues. The results indicated that high expression of HOTAIR in bladder cancer was associated with advanced stage and high grade (P<0.05). Kapaln-Meier survival analysis suggested that patients with high HOTAIR expression was associated with poor overall survival(P<0.05). Multivariate analysis revealed that HOTAIR expression was an independent predictor of overall survival. Conclusions: HOTAIR might play a positive role in bladder cancer development and could serve as an biomarker for overall survival of bladder cancer. |
| Keywords: | long non-coding RNA HOTAIR bladder cancer |
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