| 62例原发性乳腺弥漫大B细胞淋巴瘤临床病例分析 |
| |
| 引用本文： | 易嘉宁,范培芝,范舟,易平勇,陈帅,杜洋.62例原发性乳腺弥漫大B细胞淋巴瘤临床病例分析[J].中国肿瘤临床,2019,46(12):606-610. |
| |
| 作者姓名： | 易嘉宁 范培芝 范舟 易平勇 陈帅 杜洋 |
| |
| 作者单位： | ①.湖南省人民医院乳甲外科（长沙市410002） |
| |
| 摘 要： | 目的:探讨原发性乳腺弥漫大B细胞淋巴瘤(primary breast diffuse large B-cell lymphoma,PBDLBCL)的临床病理特点、治疗方案及预后。方法:收集湖南省人民医院、湖南省肿瘤医院和邵阳珂信肿瘤医院2006年1月至2016年12月62例PBDLBCL患者的临床病理资料,采用Kaplan-Meier法进行单因素分析,多因素分析采用Cox回归模型。结果:62例患者均为女性,年龄26~71岁,中位年龄47岁。随访6~105个月,3年患者总生存率(overall survival,OS)为71.0%,5年OS为51.0%。单因素生存分析显示,临床分期、IPI评分、化疗方案、Ki-67、LDH水平、Myc/Bcl-2蛋白共表达的患者3、5年OS差异具有统计学意义(P<0.05)。Cox回归模型多因素分析结果显示,Myc/Bcl-2蛋白共表达为影响患者预后的独立因素。结论:Myc/Bcl-2蛋白共表达为影响患者预后的独立因素,治疗仍以免疫化疗为主,结合局部放疗。
|
| 关 键 词： | 乳腺肿瘤 淋巴瘤 临床特征 预后 |
| 收稿时间： | 2019-04-29 |
Retrospective analysis of clinical characteristics and prognostic factors of primary breast diffuse large B-cell lymphoma |
| |
| Jianing Yi,Peizhi Fan,Zhou Fan,Pingyong Yi,Shuai Chen,Yang Du.Retrospective analysis of clinical characteristics and prognostic factors of primary breast diffuse large B-cell lymphoma[J].Chinese Journal of Clinical Oncology,2019,46(12):606-610. |
| |
| Authors: | Jianing Yi Peizhi Fan Zhou Fan Pingyong Yi Shuai Chen Yang Du |
| |
| Affiliation: | ①.Surgical Department of Breast and Thyroid Gland, Hunan Provincial People's Hospital, Changsha 410002, China②.Clinical Laboratory, Hunan Cancer Hospital, Changsha 410002, China③.Department of Medical Oncology Shao Yang Kexin Cancer Hospital, Shaoyang 422000, China |
| |
| Abstract: | Objective To study the clinical and pathological characteristics and prognostic factors of primary breast diffuse large B-cell lymphoma (PBDLBCL). Methods Clinical and pathological data of 62 patients with PBDLBCL from January 2006 to December 2016 were retrospectively analyzed.The Kaplan-Meier method was used for univariate analysis and the Cox regression model for multivariate analysis. Results The 62 patients analyzed included women aged 26-71 years, with a median age of 47 years.Patients were followed up from 6 to 105 months; the 3-year overall survival (OS) rate was 71.0%, and 5-year OS rate was 51.0%.The univariate analysis showed statistically significant differences in the clinical stage, lactic acid dehydrogenase level, International Prognostic Index score, Myc/Bcl-2 protein expression, and chemotherapy regimen at 3 and 5 years associated with OS rates.The multivariate analysis showed that Myc/Bcl-2 protein expression was an independent prognostic factor of OS. Conclusions Comprehensive treatment with chemotherapy and radiotherapy is appropriate for PBDLBCL.Myc/Bcl-2 protein expression is an independent adverse prognostic factor for PBDLBCL. |
| |
| Keywords: | breast neoplasm diffuse large B-cell lymphoma clinical characteristics prognosis |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载全文 |
|
