Cryptococcal meningitis due to Cryptococcus neoformans genotype AFLP1/VNI in Iran: a review of the literature |
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| Authors: | Hamid Badali Shahriar Alian Hamed Fakhim Mahsa Falahatinejad Ali Moradi Mehrnaz Mohammad Davoudi Ferry Hagen Jacques F. Meis |
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| Affiliation: | 1. Department of Medical Mycology and Parasitology/Invasive Fungi Research Center (IFRC), Mazandaran University of Medical Sciences, Sari, Iran;2. Department of Infectious Disease, Antimicrobial Resistance Research Center (ARRC), Mazandaran University of Medical Sciences, Sari, Iran;3. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran;4. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands;5. Department of Medical Microbiology, Radboudumc, Nijmegen, The Netherlands |
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| Abstract: | Cryptococcal meningitis is the most important opportunistic fungal infection with a high mortality in HIV‐patients in less developed regions. Here, we report a case of cryptococcal meningitis in a 49‐year‐old HIV‐positive female due to Cryptococcus neoformans (serotype A, mating‐type alpha, genotype AFLP1/VNI) in Sari, Iran. In vitro antifungal susceptibility tests showed MICs of isavuconazole (0.016 μg ml?1), voriconazole (0.031 μg ml?1), posaconazole (0.031 μg ml?1), itraconazole (0.063 μg ml?1), amphotericin B (0.125 μg ml?1) and fluconazole (8 μg ml?1). Despite immediate antifungal therapy, the patient died 4 days later due to respiratory failure. Cryptococcal infections have been infrequently reported from Iran and therefore we analysed all published cases of cryptococcosis in Iran since the first reported case from 1969. |
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| Keywords: | Cryptococcus species
HIV
molecular identification Iran |
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