| P16 P53 CyclinD1在卵巢浆液性癌中的表达及意义 |
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| 引用本文： | 赵立武,申彦,师宜荃,刘艳,刘易欣.P16 P53 CyclinD1在卵巢浆液性癌中的表达及意义[J].中国肿瘤临床,2012,39(7):388-391. |
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| 作者姓名： | 赵立武 申彦 师宜荃 刘艳 刘易欣 |
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| 作者单位： | ①.天津医科大学中心妇产临床学院病理科（天津市 300100） |
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| 摘 要： | 目的 探讨卵巢高、低级别浆液性癌中P16蛋白、P53蛋白、CvclinDl蛋白的表达情况及意义。 方法 应用免疫组化法对45例卵巢浆液性癌(低级别19例, 高级别26例)及25例卵巢交界性浆液性囊腺瘤组织进行P16、P53、CvclinD1蛋白检测, 并分析其意义。 结果 P53在低级别癌中阳性表达率为5%, 显著低于高级别癌中的69%(P < 0.05), 而CyclinD1在低级别癌中阳性表达率为89%, 显著高于高级别癌中的15%(P < 0.05), P53和CvclinDl表现为负相关(r=0.211)。P16在低、高级别癌肿的阳性表达率分别为84%和92%, 高级别癌阳性率高于低级别癌, 但差异无统计学意义(P>0.05)。 结论 P53和CyclinDl在卵巢高、低级别浆液性癌中的表达有显著差异, 对于形态上介于高、低级别之间的浆液性癌, 二者可能成为分级的辅助手段。
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| 关 键 词： | P16 P53 CyclinD1 卵巢肿瘤 浆液性癌 |
| 收稿时间： | 2012-02-04 |
Expression of P16, P53, and CyclinD1 Protein in Low-grade and High-grade Ovarian Serous Carcinoma and Its Clinical Significance |
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| Liwu ZHAO
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Yan SHEN
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Yiquan SHI
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Yan LIU
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Yixin LIU.Expression of P16, P53, and CyclinD1 Protein in Low-grade and High-grade Ovarian Serous Carcinoma and Its Clinical Significance[J].Chinese Journal of Clinical Oncology,2012,39(7):388-391. |
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| Authors: | Liwu ZHAO Yan SHEN Yiquan SHI Yan LIU Yixin LIU |
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| Affiliation: | ①.Department of Pathology, Tianjin Central Hospital of Gynecology and Obstetrics of Tianjin Medical University, Tianjin 300100, China②.Department of Gynaecology and Obstetrics, Ninghe Country Hospital, Tianjin 301500, China |
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| Abstract: | Objective To investigate the expression of P16, P53, and CyclinD1 protein in low-grade and high-grade ovarian serous carcinoma and its clinical significance. The clinical data and pathological findings were analyzed. Methods Fourty five cases of ovarian serous carcinoma (19 cases of low-grade and 26 cases of high-grade carcinoma) and 25 cases of borderline ovarian serous tumors were selected. Immunohistochemical study of P16, P53, and CyclinD1 was performed in all 70 cases. Results The high-grade serous carcinoma had a significantly higher expression level of P53 (69% versus 5%), while low-grade carcinoma had a significantly higher expression level of CyclinD1 (89% versus 15%). Significant differences were observed in the expression between P53 and CyclinD1. An inverse correlation existed between the expression of P53 and CyclinD1 in tumor grade, r = 0.211. No difference was observed in the expression of P16 between low-grade and high-grade ovarian serous carcinoma (84% versus 92%). Conclusion P53 over-expression was more frequently detected in high-grade than on low-grade ovarian serous carcinoma. CyclinD1 over-expression was more frequently detected in low-grade ovarian serous carcinomas. Conventional high-grade serous adenocarcinoma is distinct from low-grade serous adenocarcinoma. P 16 over-expression was detected more frequently in ovarian serous carcinoma. |
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