Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice |
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| Authors: | Puliti Manuela von Hunolstein Christina Bistoni Francesco Orefici Graziella Tissi Luciana |
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| Affiliation: | Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. |
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| Abstract: | The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1 beta production. |
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