| 冀东满族肺腺癌患者胸液与相应肿瘤组织EGFR基因突变检测对比分析 |
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| 引用本文： | 贾 瑞,薛 雷,杜海荣,杨宏伟,高 鲲,梁华刚.冀东满族肺腺癌患者胸液与相应肿瘤组织EGFR基因突变检测对比分析[J].现代肿瘤医学,2015,0(12):1676-1678. |
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| 作者姓名： | 贾 瑞 薛 雷 杜海荣 杨宏伟 高 鲲 梁华刚 |
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| 作者单位： | 1.秦皇岛市第一医院，河北 秦皇岛 066000；
2.秦皇岛市卢龙县人民医院，河北 秦皇岛 066400 |
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| 摘 要： | 目的:分析冀东满族肺腺癌患者胸液与相应肿瘤组织EGFR基因突变检测结果。方法:选取2010年9月至2014年9月间在我院胸外科治疗的74例有胸液的冀东满族肺腺癌患者为研究对象，采用变性高效液相色谱法(DHPLC)检测肺腺癌患者胸液及相应肿瘤组织样本中是否发生EGFR基因突变。结果:肿瘤组织EFGR基因突变检出率为50.00%，胸液样本EGFR基因突变检出率为52.70%，两者间无统计学差异(P＞0.05)。胸液上清、胸液沉淀、胸液上清与沉淀以及肿瘤组织EGFR基因检测结果一致性均良好。结论:肺腺癌患者胸液与相应肿瘤组织EGFR基因突变检测结果一致性良好，临床可通过胸液检测代替肿瘤组织检测，以期能够持续监测患者EGFR基因突变状态，以指导患者添加或者实施EGFR-TKIs治疗。
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| 关 键 词： | 肺腺癌患者 胸液 相应肿瘤组织 EGFR基因突变检测 |
Comparative analysis of EGFR gene mutation status of pleural effusion and matched metastatic pleural tumor tissue in Manchu patients who live in east of Hebei with lung adenocarcinoma |
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| Jia Rui,Xue Lei,Du Hairong,Yang Hongwei,Gao Kun,Liang Huagang.Comparative analysis of EGFR gene mutation status of pleural effusion and matched metastatic pleural tumor tissue in Manchu patients who live in east of Hebei with lung adenocarcinoma[J].Journal of Modern Oncology,2015,0(12):1676-1678. |
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| Authors: | Jia Rui Xue Lei Du Hairong Yang Hongwei Gao Kun Liang Huagang |
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| Affiliation: | 1.Qinhuangdao First Hospital，Hebei Qinhuangdao 066000,China；2.Lulong County People's Hospital,Hebei Qinhuangdao 066400,China. |
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| Abstract: | Objective:To compare the EGFR gene mutation status of pleural effusion and matched metastatic pleural tumor tissue in Manchu patients with lung adenocarcinoma.Methods:All 74 patients of lung adenocarcinoma with pleural effusion treated in our hospital from September 2010 to September 2014 were selected as the research objects.EGFR gene mutation status was determined by denaturing high performance liquid chromatography.Results:The EGFR gene mutation rate was 50.00% in the matched metastatic pleural tumor tissue samples.While the EGFR gene mutation rate was 52.70% in the pleural effusion samples.There was no statistically significant difference between them(P＞0.05).The concordance rate among matched metastatic pleural tumor tissue,malignant pleural effusions cell-block,malignant pleural effusions supernatants,malignant pleural effusions supernatants and cell-block were good.Conclusion:The concordance rate among matched metastatic pleural tumor tissue,malignant pleural effusions cell-block,malignant pleural effusions supernatants,malignant pleural effusions supernatants and cell-block were good.It is good for giving guidance of applying or adding epidermal growth factor receptor-tyrosine kinase inhibitors. |
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| Keywords: | lung adenocarcinoma pleural effusion matched metastatic pleural tumor tissue EGFR gene mutation status |
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