| 多西紫杉醇联合替吉奥、奥沙利铂治疗晚期胃癌的临床观察 |
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| 引用本文： | 陈习波,宋华志,何远春,刘 勇.多西紫杉醇联合替吉奥、奥沙利铂治疗晚期胃癌的临床观察[J].现代肿瘤医学,2015,0(10):1417-1419. |
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| 作者姓名： | 陈习波 宋华志 何远春 刘 勇 |
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| 作者单位： | 六安市人民医院肿瘤中心 安徽医科大学附属六安医院，安徽 六安 237005 |
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| 基金项目： | 卫生部医药卫生科技发展研究中心课题(编号:W2012FZ140) |
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| 摘 要： | 目的:观察多西紫杉醇联合替吉奥、奥沙利铂治疗晚期胃癌患者的有效性及安全性。方法:选择2011年4月-2014年5月来我院治疗的40例晚期胃癌患者，按照随机数字表法分为实验组和对照组，每组20例。对照组患者给予奥沙利铂、5-氟尿嘧啶和亚叶酸钙诊治，实验组患者采用多西紫杉醇联合替吉奥、奥沙利铂治疗。结果:实验组完全缓解（CR）10例，部分缓解（PR）7例，稳定（SD）1例，进展（PD）2例，临床有效率为90.0%。对照组完全缓解（CR）4例，部分缓解（PR）4例，稳定（SD）2例，进展（PD）10例，临床有效率为50.0%，两组患者的临床有效率存在明显差异性，具有统计学意义（P＜0.05）；两组患者治疗后均发生消化道反应、白细胞减少、口腔黏膜炎、周围神经毒性、肝功能异常等不良反应，但实验组患者的不良反应发生率为40.0%，显著低于对照组患者的65.0%的不良反应发生率（P＜0.05）；治疗后，两组患者的生活质量均有提高，但实验组的Karnofsky's评分升高更具优势，两组有明显差异性（P＜0.05）。结论:多西紫杉醇联合替吉奥、奥沙利铂治疗晚期胃癌患者，能够显著提高临床有效率，明显降低不良反应发生率，提高患者生活质量，是晚期胃癌患者治疗的一种有效方法。
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| 关 键 词： | 多西紫杉醇 替吉奥联 奥沙利铂 有效性及安全性 |
Efficacy and safety of Gio docetaxel,oxaliplatin treatment on advanced gastric cancer |
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| Chen Xibo,Song Huazhi,He Yuanchun,Liu Yong.Efficacy and safety of Gio docetaxel,oxaliplatin treatment on advanced gastric cancer[J].Journal of Modern Oncology,2015,0(10):1417-1419. |
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| Authors: | Chen Xibo Song Huazhi He Yuanchun Liu Yong |
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| Affiliation: | Cancer Center,Lu'an People's Hospital,Anhui Lu'an Hospital Affiliated to Medical University，Anhui Lu'an 237005,China. |
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| Abstract: | Objective:Gio Cha Duoxi paclitaxel,oxaliplatin on patients with advanced gastric cancer treatment efficacy and safety were observed.Methods:All 40 patients with advanced gastric cancer were divided into experimental group and control group,20 patients in each group.In the control group were treated with oxaliplatin,5-fluorouracil and leucovorin,the experimental group were treated with docetaxel Gio,oxaliplatin.Results:The patients with complete remission (CR) were 10 cases,partial remission (PR) 7 cases,stable (SD) 1 cases,progress (PD) 2 cases,the effective rate was 90.0% in experimental group.Control patients complete remission (CR) 4 cases,partial remission (PR) 4 cases,stable (SD) 2 cases,progress (PD) 10 cases,the effective rate was 50.0% (P＜0.05),Gastrointestinal reactions,neutropenia,oral mucositis,peripheral neurotoxicity,liver dysfunction and other adverse reactions,in the experimental group was 40.0%,significantly lower than 65.0% in the control group (P＜0.05),after treatment,the patient's quality of life in both groups had improved,but the experimental group Karnofsky's score increased more(P＜0.05).Conclusion:Gio docetaxel,oxaliplatin can significantly improve clinical efficiency,reduced the incidence of adverse reactions and improve the quality of life for advanced gastric cancer patients. |
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| Keywords: | docetaxel Gio Union oxaliplatin efficacy and safety |
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