| 内皮抑素不同给药途径联合阿霉素治疗鼠肝移植瘤 |
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| 引用本文： | 王泽新,汪森明,周琪,胡喜钢,朱伟良,孟辉,张积仁.内皮抑素不同给药途径联合阿霉素治疗鼠肝移植瘤[J].南方医科大学学报,2010,30(8):1903-1905. |
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| 作者姓名： | 王泽新 汪森明 周琪 胡喜钢 朱伟良 孟辉 张积仁 |
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| 作者单位： | 重庆市涪陵中心医院肿瘤科，重庆408000； 南方医科大学珠江医院肿瘤中心，广东广州510282 |
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| 摘 要： | 目的 研究内皮抑素(Es)瘤内与尾静脉两种给药途径联合腹腔注射阿霉素(Adm)对小鼠H22肝癌细胞移植瘤血管生成和肿瘤生长的抑制作用.方法 将H22肝癌细胞接种到40只小鼠的背部皮下,肿瘤直径约1 cm时按体重随机分成4组;对照组:隔日瘤内、腹腔注射生理盐水;Es瘤内组:隔日瘤内注射Es+腹腔注射Adm;Es静脉组:隔日静脉推注Es+腹腔注射Adm;Adm组:隔日静脉推注生理盐水+腹腔注射Adm.每3 d测量皮下肿瘤直径.绘制肿瘤生长曲线,第15天每组处死5只小鼠,检测血浆VEGF含量、肿瘤组织微血管密度(MVD),观察剩余小鼠生存期.结果 Es瘤内组小鼠肿瘤体积大小、VEGF及MVD表达均小于其他3组(P<0.05),Es瘤内组生存期与Es静脉组比较均较阿霉素组、对照组延长(P<0.05),但两者生存期差异无统计学意义(P>0.05).结论 Es联合Adm在抑制血管生成与肿瘤生长方面,瘤内应用Es抑瘤效果优于静脉应用,但前者小鼠生存期的延长较后者无明显优势.
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| 关 键 词： | 内皮抑素 阿霉素 肝肿瘤 血管内皮生长因子 |
Endostatin in different administration routes combined with adriamycin chemotherapy in the treatment of liver cancer xenograft in mice |
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| WANG Ze-xin,WANG Sen-ming,ZHOU Qi,HU Xi-gang,ZHU Wei-liang,MENG Hui,ZHANG Ji-ren.Endostatin in different administration routes combined with adriamycin chemotherapy in the treatment of liver cancer xenograft in mice[J].Journal of Southern Medical University,2010,30(8):1903-1905. |
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| Authors: | WANG Ze-xin WANG Sen-ming ZHOU Qi HU Xi-gang ZHU Wei-liang MENG Hui ZHANG Ji-ren |
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| Affiliation: | WANG Ze-xin1,WANG Sen-ming2,ZHOU Qi1,HU Xi-gang2,ZHU Wei-liang2,MENG Hui2,ZHANG Ji-ren2 1Department of Oncology,Chongqing Fuling Central Hospital,Chongqing 408000,China,2Department of Oncology,Zhujiang Hospital,Southern Medical University,Guangzhou 510282 |
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| Abstract: | Objective To study the antiangiogenetic and tumor inhibitory effects of endostatin (Es) by intratumoral versus intravenous administration combined with adriamycin (Adm) for treatment of transplanted tumor in mice. Methods Forty mice were subjected to subcutaneous implantation of H22 cells and randomly divided into 4 groups by the body weight when the tumor diameter reached 1 cm, namely the control group (with intratumoral and intravenous injection of normal saline), Es intratumoral group (with intratumoral ... |
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| Keywords: | endostatin adriamycin liver neoplasm vascular endothelial growth factor |
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