| 胆囊结石患者微创保胆取石术前超声诊断效能及术后复发的高危因素 |
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| 作者姓名： | 邓杰文 唐卫东 杨秀林 姜超 许承 |
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| 作者单位： | 四川省科学城医院普外科，四川 绵阳 621000 |
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| 基金项目： | 绵阳市卫健委立项科研项目202002 |
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| 摘 要： | 目的 分析胆囊结石患者微创保胆取石术前彩色多普勒超声（CDFI）诊断效能及术后复发的高危因素。 方法 选取2017年1月~2020年1月本院收治的90例拟行微创保胆取石术的胆囊结石患者为研究对象，所有患者在术前均接受CDFI检查，观察胆囊结石患者CDFI表现，并以手术结果为金标准，采用Kappa检验评价其诊断结果的一致性，采用ROC曲线评估CDFI诊断胆囊结石的效能，计算曲线下面积；术后随访2年，统计胆囊结石复发情况，采用单因素和多因素Logistic回归分析影响患者术后复发的高危因素。 结果 术前，胆囊内结石表现为不规则形、圆形或类圆形低信号影；胆囊保肝取石术后，大小约4.9 cm×1.8 cm，壁增厚，约1.3 cm，内壁见点状强回声附着，后方伴彗星尾，腔内透声好，胆囊未见明显积液；90例患者中，金标准诊断显示阳性81例，阴性9例，CDFI诊断显示阳性74例，阴性16例，其诊断结果与手术一致性较好（Kappa值=0.524）；ROC曲线显示，CDFI诊断胆囊结石的曲线下面积为0.840，敏感度为90.12%，特异性为77.78%；术后随访2年，有12例患者复发，单因素和多因素Logistic回归分析结果显示，胆石症家族史、胆囊壁厚度、结石数量均是影响胆囊结石患者术后复发的高危因素（P < 0.05）。 结论 CDFI对胆囊结石患者微创保胆取石术前诊断具有较好的效能，胆石症家族史、胆囊壁厚度、结石数量均是胆囊结石患者术后复发的高危因素。
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| 关 键 词： | 胆囊结石 微创保胆取石术 超声 诊断效能 术后复发 高危因素 |
| 收稿时间： | 2022-07-14 |
Diagnostic efficacy of ultrasound before minimally invasive cholelithiasis and the risk factors of postoperative recurrence in patients with cholecystolithiasis |
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| Authors: | DENG Jiewen TANG Weidong YANG Xiulin JIANG Chao XU Cheng |
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| Affiliation: | Department of General Surgery, Sichuan Science City Hospital, Mianyang 621000, China |
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| Abstract: | Objective To analyze the diagnostic efficacy of preoperative color Doppler flow image (CDFI) and the risk factors of postoperative recurrence in patients with cholecystolithiasis with minimally invasive cholelithotomy. Methods A total of 90 patients with cholecystolithiasis who were proposed to undergo minimally invasive gallbladder-preserving lithotomy treated in our hospital from January 2017 to January 2020 were selected. All patients underwent CDFI examination before surgery, and the manifestations of CDFI in patients with cholecystolithiasis were observed. Using surgical results as the gold standard, Kappa test was used to evaluate the consistency of the diagnostic results, ROC curve was used to evaluate the efficacy of CDFI in diagnosing gallbladder stones, and AUC was calculated. Follow-up for 2 years after operation, the recurrence of cholecystolithiasis was counted, and univariate and multivariate Logistic regression was used to analyze the high-risk factors for postoperative recurrence. Results Before operation, the gallbladder stones were irregular, round or quasi-round low signal shadows. After gallbladder hepatoprotective lithotripsy, the size was about 4.9 cm ×1.8 cm, the wall was thickened, with the thickness of 1.3 cm, and the inner wall saw dot strong echo attachment, rear accompanied by the comet tail, good sound in the cavity, gallbladder did not see obvious effusion. Among the 90 patients, 81 cases were positive and 9 cases were negative by gold standard diagnosis, 74 cases were positive and 16 cases were negative by CDFI diagnosis, the diagnostic results were in good agreement with surgery (Kappa value=0.524). The ROC curve showed that the AUC of CDFI in diagnosing gallstones was 0.840, with a sensitivity of 90.12% and a specificity of 77.78%. After 2 years of postoperative follow-up, there were 12 cases had relapsed. Univariate and multivariate Logistic regression analysis showed that the family history of cholelithiasis, the thickness of the gallbladder wall, and the number of stones were all high risk factors for postoperative recurrence in patients with cholecystolithiasis (P < 0.05). Conclusion CDFI has a good effect on the preoperative diagnosis of cholecystolithiasis patients with minimally invasive gallbladder-preserving lithotomy. Family history of cholelithiasis, thickness of gallbladder wall, and number of stones are high risk factors for postoperative recurrence in patients with cholecystolithiasis. |
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