| 代谢应激和胰腺癌的发生发展 |
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| 引用本文： | 李金涛,雷明珠,雷群英,尹淼.代谢应激和胰腺癌的发生发展[J].四川大学学报(医学版),2021,52(1):5-10. |
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| 作者姓名： | 李金涛 雷明珠 雷群英 尹淼 |
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| 作者单位： | 复旦大学附属肿瘤医院肿瘤研究所,上海 200032;复旦大学上海医学院肿瘤学系,上海 200032;复旦大学附属肿瘤医院肿瘤研究所,上海 200032;复旦大学上海医学院肿瘤学系,上海 200032;复旦大学附属肿瘤医院肿瘤研究所,上海 200032;复旦大学上海医学院肿瘤学系,上海 200032;复旦大学附属肿瘤医院肿瘤研究所,上海 200032;复旦大学上海医学院肿瘤学系,上海 200032 |
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| 基金项目： | 国家自然科学基金（No. 82002951、No. 81872240）资助 |
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| 摘 要： | 目前胰腺导管腺癌（PDAC）的有效临床治疗方案有限，5年生存率低于8%，因此迫切需要探索新的治疗策略。PDAC为了适应极端恶劣的微环境，在其演进过程中存在广泛的代谢重编程。代谢应激与癌基因激活（如KRAS）以及抑癌基因失活所触发的信号密切相关。同时，代谢异常重塑肿瘤微环境，协同促进PDAC的发展。本篇综述将重点阐述PDAC及其微环境中的代谢重编程，以探索PDAC治疗中潜在的靶标。
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| 关 键 词： | 胰腺导管腺癌 代谢 肿瘤微环境 |
| 收稿时间： | 2020-11-04 |
A Review of Metabolic Stress and Development of Pancreatic Cancer |
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| LI Jin-tao,LEI Ming-zhu,LEI Qun-ying,YIN Miao.A Review of Metabolic Stress and Development of Pancreatic Cancer[J].Journal of West China University of Medical Sciences,2021,52(1):5-10. |
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| Authors: | LI Jin-tao LEI Ming-zhu LEI Qun-ying YIN Miao |
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| Affiliation: | 1.Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China |
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| Abstract: | Pancreatic ductal adenocarcinoma (PDAC) is one of the most notorious malignancies with a 5-year survival rate of less than 8%. Therefore, it is crucial to investigate the molecular mechanism underlining PDAC initiation, promotion, and progression for efficient treatment of PDAC. In order to adapt and survive in an extremely adverse microenvironment of hypoxia and insufficiency of nutrients and energy, PDAC cells undergo extensive metabolic modification triggered by intrinsic signalings which are activated by different genetic events, including mutations occurred at KRAS, TP53, and DPC4/SMAD4, collaboratively promoting PDAC development. Notably, PDCA cells have extensive crosstalk in the form of reciprocal metabolic flux with its surrounding microenvironment to facilitate tumor advancement and therapy resistance. We herein summarize recent findings of PDAC metabolism and discuss metabolic rewiring-based therapeutic strategies. |
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