| 肌少症研究进展 |
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| 作者姓名： | 何盼 刘月涛 杜冠华 秦雪梅 |
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| 作者单位： | 1. 山西大学中医药现代研究中心，太原，030006，中国
2. 中国医学科学院北京协和医学院药物研究所，北京，100050，中国 |
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| 基金项目： | 山西省研究生教育创新项目（No.2020BY010） |
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| 摘 要： | 肌少症是一种随着年龄增长，骨骼肌的质量、力量及功能均下降的老年综合征，具有发病率高、病因复杂的特点，容易造成老年人丧失生活能力、生活质量下降，因此，早期诊断、预防和治疗肌少症具有重要的临床和现实意义。该文系统地对肌少症的病理机制、目前中西医的治疗现状及相关疾病模型进行了综述，为开展肌少症的机制研究及治疗药物筛选提供参考。
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| 关 键 词： | 肌少症 病理机制 治疗 疾病模型 衰老 |
Research Advances in Sarcopenia |
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| Authors: | HE Pan LIU Yue-tao DU Guan-hua QIN Xue-mei |
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| Affiliation: | 1. Modern Research Center for Traditional Chinese Medicine，Shanxi University，Taiyuan，030006，China
2. Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing，100050，China
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| Abstract: | Sarcopenia is an age-related，progressive syndrome，which is characterized by decline of skeletal muscle mass，strength and muscle function. It has high morbidity and complex pathogenesis. Then it leads to the loss of life ability and the decline in life quality of the aged. It is significant to diagnose，prevent and treat sarcopenia early in clinic and practice. In this review，etiology and pathological mechanism of sarcopenia，present treatment and models of the disease are summarized systematically，which could provide a reference for exploring its machenism deeply and screening drugs of the prevention and treatment of sarcopenia. |
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| Keywords: | sarcopenia pathogenesis treatment model of disease aging |
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