| 月桂氮卓酮对阿司匹林乳膏体外释药的影响 |
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| 引用本文： | 王秀,顾亚洲,钱江华,吴华璞. 月桂氮卓酮对阿司匹林乳膏体外释药的影响[J]. 蚌埠医学院学报, 2010, 35(10): 1046-1047,1050. DOI: 10.3969/j.issn.1000-2200.2010.10.030 |
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| 作者姓名： | 王秀 顾亚洲 钱江华 吴华璞 |
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| 作者单位： | 蚌埠医学院药剂学教研室, 安徽蚌埠 233030 |
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| 基金项目： | 蚌埠医学院自然科学基金资助项目 |
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| 摘 要： | 目的:探讨月桂氮卓酮对阿司匹林乳膏体外透皮作用的影响。方法:制备含不同浓度月桂氮卓酮的阿司匹林乳膏作用于小鼠离体皮肤,用改良Franz扩散池法收集接受液,紫外法测定药物单位面积累积渗透量、平均渗透速率、渗透系数。结果:含5%和10%月桂氮卓酮乳膏平均渗透速率分别比不含月桂氮卓酮乳膏增加10.6%和25.0%。结论:不同浓度的月桂氮卓酮均可促进阿司匹林透过小鼠皮肤,阿司匹林从乳剂型基质向皮肤的渗透符合Higuchi方程。
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| 关 键 词： | 阿司匹林 月桂氮卓酮 透皮吸收 |
| 收稿时间： | 2009-06-30 |
Effects of laccrocapram on percutaneous absorption of aspirin cream |
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| WANG Xiu,GU Ya-zhou,QIAN Jiang-hua,WU Hua-pu. Effects of laccrocapram on percutaneous absorption of aspirin cream[J]. Journal of Bengbu Medical College, 2010, 35(10): 1046-1047,1050. DOI: 10.3969/j.issn.1000-2200.2010.10.030 |
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| Authors: | WANG Xiu GU Ya-zhou QIAN Jiang-hua WU Hua-pu |
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| Affiliation: | Department of Pharmaceutics, Bengbu Medical College, Bengbu Anhui 233030, China |
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| Abstract: | Objective：To study the effect of laccrocapram on percutaneous absorption of aspirin cream across mice skin in vitro.Methods：Fluids were collected by using Franz diffusion cells after permeation through the skin of mice.And the per square centimeter′s accumulative permeation quantity,steady percutaneous speed and permeation coefficient were determined by ultra-violet spectroscopy.Results：Steady percutaneous speed of acetyl salicylic acid cream with 5% and 10% laccrocapram increased 10.6% and 25.0%,respectively.Conclusions：Different concentrations of laccrocapram can increasing permeation of acetyl salicylic acid.The permeation from emulsion base conformed to Higuchi equation. |
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| Keywords: | aspirin laccrocapram percutaneous absorption |
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