| 三维适形放射治疗联合替吉奥化学治疗局部复发性直肠癌32例 |
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| 引用本文： | 舒诚荣,曹爱玲,章永,王汉姣,周剑,何玲.三维适形放射治疗联合替吉奥化学治疗局部复发性直肠癌32例[J].骨科,2015,34(4):452-454. |
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| 作者姓名： | 舒诚荣 曹爱玲 章永 王汉姣 周剑 何玲 |
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| 作者单位： | 湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100,湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100,湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100,湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100,湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100,湖北省咸宁市中心医院、华中科技大学同济咸宁医院肿瘤中心,咸宁437100 |
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| 摘 要： | 目的观察三维适形放射治疗(放疗)联合替吉奥化学治疗(化疗)局部复发直肠癌的安全性与可行性。方法32例经证实的局部复发直肠癌患者接受全盆腔三维适形放疗DT45Gy/25F,后缩野至肿瘤复发区推量至63Gy/35F,同期口服替吉奥胶囊80 mg·(m2)-1·d-1(d1～5,d8～12,d15～19,d22～26,d29～33,d36～40,d43～47)。结果有1例患者口服替吉奥胶囊1周后出现4级血小板下降,停用化疗,只完成放疗,其他患者均完成放疗和化疗。32例患者中,完全缓解3例(9.4%),部分缓解21例(65.6%),总有效率为75.0%;1和2年生存率分别为71.0%和56.5%;疼痛缓解率为96.9%。主要毒性反应为消化道反应和血液学毒性,有1例出现4级血小板下降,有2例出现3级白细胞下降,有1例出现3级腹泻,3～4级毒性反应发生率为12.5%。结论三维适形放疗联合替吉奥化疗治疗局部复发性直肠癌方法,近期疗效可靠,患者依从性好,毒性反应可耐受。
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| 关 键 词： | 替吉奥 癌 直肠 复发 局部 放射治疗 化学治疗 放射治疗 三维适形 |
Three-Dimensional Conformal Radiation Therapy Combined with Tegafur for 32 Cases of Locally Recurrent Rectal Cancer |
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| SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling,SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling,SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling,SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling,SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling and SHU Chengrong,CAO Ailing,ZHANG Yong,WANG Hanjiao,ZHOU Jian,HE Ling.Three-Dimensional Conformal Radiation Therapy Combined with Tegafur for 32 Cases of Locally Recurrent Rectal Cancer[J].Orthopaedics,2015,34(4):452-454. |
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| Authors: | SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling and SHU Chengrong CAO Ailing ZHANG Yong WANG Hanjiao ZHOU Jian HE Ling |
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| Abstract: | ObjectiveTo evaluate the safety and feasibility of three-dimensional conformal radiation therapy combined with tegafur in treating locally recurrent rectal cancer.MethodsA total of 32 patients with locally recurrent rectal cancer were treated with chemoradiotherapy (CRT). Radiotherapy was delivered to a total of 45 Gy in 25 fractions followed by a boost of 18 Gy in 10 fractions using three dimensional radiotherapy planning.Tegafur was given orally80 mg·(m2)-1·d-1] on days 1-5, 8-12, 15-19, 22-26, 29-33, 36-40, and 43-47 during radiotherapy.ResultsMost of the adverse effects were mild.Grade 3-4 toxic effects occurred in 12.5% of patients.Thirty-one patients completed full course of CRT, while one patient discontinued chemotherapy due to Grade 4 thrombocytopenia.There were 3 cases (9.4%) with complete response, 21 cases (65.6%) with partial response, and the overall response rate was 75.0%.Overall pain response (complete and partial pain relief) was achieved in 96.9% of patients.The1-and2-year overall survival rate was 71.0% and 56.5%, respectively.Conclusion3D-CRT combined with tegafur for locally recurrent rectal cancer is feasible with high patient compliance and tolerable toxicities. |
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| Keywords: | Tegafur Cancer rectal Recurrent locally Rediation therapy Chemotherapy Radiotherapy three-dimensional conformal |
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